A statistical approach to determine fluxapyroxad and its three metabolites in soils, sediment and sludge based on a combination of chemometric tools and a modified quick, easy, cheap, effective, rugged and safe method

文献类型: 外文期刊

第一作者: Liu, Xingang

作者: Liu, Xingang;Zhu, Yulong;Dong, Fengshou;Xu, Jun;Zheng, Yongquan;Li, Minmin

作者机构:

关键词: Fluxapyroxad;Metabolites;Experimental design;Soils;Sediment;Sludge

期刊名称:JOURNAL OF CHROMATOGRAPHY A ( 影响因子:4.759; 五年影响因子:4.302 )

ISSN:

年卷期:

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收录情况: SCI

摘要: An effective method for the quantification of fluxapyroxad and its three metabolites in soils, sediment and sludge was developed using ultrahigh performance chromatography coupled with tandem mass spectrometry (UHPLC-MS/MS). Both the extraction and clean-up steps of the QuEChERS procedure were optimised using a chemometric tool, which was expected to facilitate the rapid analysis with minimal procedures. Several operating parameters (MeCN/acetic acid ratio in the extraction solution (i.e., acetic acid percentage), water volume, extraction time, PSA amount, C_(18) amount, and GCB amount) were investigated using a Plackett-Burman (P-B) screening design. Afterward, the significant factors (acetic acid percentage, water volume, and PSA amount) obtained were optimised using central composite design (CCD) combined with the desirability function (DF) to determine the optimum experimental conditions. The optimised procedure provides high-level linearity for all studied compounds with correlation coefficients ranging between 0.9972 and 0.9999. The detection limits were in the range of 0.1 to 1.0 μg/kg and the limits of quantitation (LOQs) were between 0.5 and 3.4 μg/kg with relative standard deviations (RSD) between 2.3% and 9.6% (n = 6). Therefore, the developed protocol can serve as a simple and sensitive tool for monitoring fluxapyroxad and its three metabolites in soil, sediment and sludge samples.

分类号: O65

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