MiR-204 promotes apoptosis in oxidative stress-induced rat Schwann cells by suppressing neuritin expression

文献类型： 外文期刊

第一作者： Gao, Rui

作者： Gao, Rui;Sun, Jun;Zhang, Haiyuan;Huang, Jin;Gao, Rui;Nie, Kun;Jian, Huiling;Liao, Xinhua;Huang, Jin;Wang, Liming;Gao, Lei;Gan, Shangquan

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关键词： javax.sql.rowset.serial.SerialClob@4df3c1

期刊名称：FEBS LETTERS （ 影响因子：4.124； 五年影响因子：3.814 ）

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收录情况： SCI

摘要： Neuritin (Nrn1) is a neurotrophin that plays an important role in nervous system plasticity and repair following nerve injury. MicroRNAs (miRNAs) are a type of small non-coding RNA that regulate nearly all aspects of nerve development and survival, including apoptosis. Here it was found that miR-204 negatively regulates Nrn1 protein expression through direct interaction with Nrn1 transcript. Moreover, miR-204 activates cleaved caspase-3, enhancing the sensitivity of RSC96 Schwann cells to H2O2-induced oxidative stress and apoptosis. Thus, miR-204 expressed at a low level may create a microenvironment suitable for the repair of injured nerves by relieving the inhibition of Nrn1 transcription and stimulating the anti-apoptotic function of Schwann cells. These results provide novel insights into the roles of miR-204 in nerve injury and repair.

分类号： Q5

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