Cloning and characterization of the mouse JDP2 gene promoter reveal negative regulation by p53

文献类型: 外文期刊

第一作者: Xu, Yuanhong

作者: Xu, Yuanhong;Liu, Zhe;Zhang, Zhongbo;Bi, Shulong;Jin, Chunyuan;Li, Hongjie;Pan, Jianzhi;Yokoyama, Kazunari K.

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关键词: JDP2;p53;Promoter;Transcriptional regulation

期刊名称:BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS ( 影响因子:3.575; 五年影响因子:3.381 )

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收录情况: SCI

摘要: Jun dimerization protein 2 (JDP2) is a repressor of transcription factor AP-1. To investigate the transcriptional regulation of the JDP2 gene, we cloned the 5′-flanking region of the mouse JDP2 gene. Primer extension analysis revealed a new transcription start site (+1). Promoter analysis showed that the region from nt -343 to nt +177 contains basal transcriptional activity. Interestingly, the tumor suppressor p53 significantly repressed the transcriptional activity of the JDP2 promoter. Given that JDP2 inhibits expression of p53, our results suggest a negative feedback loop between JDP2 and p53, and a direct link between JDP2 and a key oncogenic pathway.

分类号: Q5

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