Rapid determination of tricaine mesylate residues in fish samples using modified QuEChERS and high-performance liquid chromatography-tandem mass spectrometry

文献类型： 外文期刊

第一作者： Li, Jincheng

作者： Li, Jincheng;Liu, Huan;Wu, Lidong;Wang, Qun;Lv, Haiyan;Ma, Bing;Song, Yi;Yu, Meiqi

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期刊名称：ANALYTICAL METHODS （ 影响因子：2.896； 五年影响因子：2.716 ）

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收录情况： SCI

摘要： A rapid and effective modified, quick, easy, cheap, effective, rugged, and safe (QuEChERS) method was developed for the determination of tricaine mesylate (MS-222) in fish samples using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Samples were extracted with the mixture of acetonitrile and acetate buffer, and then cleaned with primary/secondary amino (PSA) absorbents. The determination of MS-222 was achieved in less than 4.0 min using an electrospray ionization source in the positive mode (ESI+). The QuEChERS method was validated by evaluating the repeatability, linearity, precision, and trueness. The limit of detection (LOD) was 2.5 μg kg~(-1) and the limit of quantification (LOQ) was 10.0 μg kg~(-1). The calibration curve was linear in the range of 2-1000 μg L~(-1) (R~2 > 0.9999). Average recoveries of MS-222 were in the range of 79.6-119.7%, with a relative standard deviation (RSD) lower than 6%.

分类号： O65

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