Induction of potential protective immunity against enterotoxemia in calves by single or multiple recombinant Clostridium perfringens toxoids

文献类型： 外文期刊

第一作者： Jiang, Zhigang

作者： Jiang, Zhigang;De, Yanyan;Chang, Jitao;Wang, Fang;Yu, Li

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期刊名称：MICROBIOLOGY AND IMMUNOLOGY （ 影响因子：1.955； 五年影响因子：1.917 ）

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收录情况： SCI

摘要： Cattle enterotoxemia caused by Clostridium perfringens toxins is a noncontagious, sporadic, and fatal disease characterized by sudden death. Strategies for controlling and preventing cattle enterotoxemia are based on systematic vaccination of herds with toxoids. Because the process of producing conventional clostridial vaccines is dangerous, expensive, and time-consuming, the prospect of recombinant toxoid vaccines against diseases caused by C. perfringens toxins is promising. In this study, nontoxic recombinant toxoids derived from -, - and epsilon-toxins of C. perfringens, namely, rCPA(247-370), rCPB and rEtxHP, respectively, were expressed in Escherichia coli. High levels of specific IgG antibodies and neutralizing antibodies against the toxins were detected in sera from calves vaccinated with either a single recombinant toxoid or a mixed cocktail of all three recombinant toxoids, indicating the potential of these recombinant toxoids to provide calves with protective immunity against enterotoxemia caused by C. perfringens

分类号： Q93

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