Enhancement of blood-brain barrier permeability is required for intravenously administered virus neutralizing antibodies to clear an established rabies virus infection from the brain and prevent the development of rabies in mice

文献类型: 外文期刊

第一作者: Huang, Chien-Tsun

作者: Huang, Chien-Tsun;Li, Zhenguang;Huang, Ying;Zhang, Guoqing;Zhou, Ming;Chai, Qingqing;Fu, Zhen F.;Li, Zhenguang;Wu, Hua;Fu, Zhen F.

作者机构:

关键词: Rabies virus;MCP-1;BBB (blood-brain barrier);VNA (virus-neutralizing antibody);Occludin;Claudin-5

期刊名称:ANTIVIRAL RESEARCH ( 影响因子:5.97; 五年影响因子:5.801 )

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收录情况: SCI

摘要: Rabies virus (RABV) is a neurotropic virus that causes fatal disease in humans and animals. Currently there is no cure for rabies once clinical signs appear. It is believed that once RABV enters the central nervous system (CNS), virus neutralizing antibodies (VNAs) in the periphery cannot pass through the blood-brain barrier (BBB) and into the CNS. Furthermore, it has been hypothesized that VNAs produced in the CNS by invading B cells, rather than those produced in the periphery and then transported into the CNS, are important in clearing RABV from the CNS. In the present study, mouse serum containing VNA was administered intravenously into mice after infection with wild-type RABV. Our studies demonstrate that exogenous administration of VNAs is crucial in the clearance of RABV from the brain and prevent the development of rabies in both immunocompetent and immunocompromised mice as long as the BBB permeability remains enhanced. This present study therefore provides a foundation for the possibility of developing VNA therapy for clinical rabies in humans.

分类号: R37

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