Recombinant rabies virus expressing the H protein of canine distemper virus protects dogs from the lethal distemper challenge

文献类型： 外文期刊

第一作者： Wang, Feng-Xue

作者： Wang, Feng-Xue;Zhang, Shu-Qin;Zhu, Hong-Wei;Yang, Yong;Sun, Na;Tan, Bin;Li, Zhen-Guang;Cheng, Shi-Peng;Wen, Yong-Jun;Li, Zhen-Guang;Fu, Zhen F.

作者机构：

关键词： Canine distemper virus;Rabies virus;Hemagglutinin gene;Replicating viral vector;Dog

期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：3.293； 五年影响因子：3.599 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： The rabies virus (RV) vector LBNSE expressing foreign antigens have shown considerable promise as vaccines against viral and bacteria diseases, which is effective and safe. We produced a new RV-based vaccine vehicle expressing 1.824 kb hemagglutinin (H) gene of the canine distemper virus (CDV) by reverse genetics technology. The recombinant virus LBNSE-CDV-H retained growth properties similar to those of vector LBNSE both in BSR and mNA cell culture. The H gene of CDV was expressed and detected by immunostaining. To compare the immunogenicity of LBNSE-CDV-H, dogs were immunized with each of these recombinant viruses by intramuscular (i.m.). The dogs were bled at third weeks after the immunization for the measurement of virus neutralizing antibody (VNA) and then challenged with virulent virus (ZJ 7) at fourth weeks. The parent virus (LBNSE) without expression of any foreign molecules was included for comparison. Dogs inoculated with LBNSE-CDV-H showed no any signs of disease and exhibited seroconversion against both RV and CDV H protein. The LBNSE-CDV-H did not cause disease in dogs and conferred protection from challenge with a lethal wild type CDV strain, demonstrating its potential value for wildlife conservation efforts. Together, these studies suggest that recombinant RV expressing H protein from CDV stimulated high levels of adaptive immune responses (VNA), and protected all dogs challenge infection. (C) 2014 Elsevier B.V. All rights reserved.

分类号： S8

  • 相关文献

[1]Characterization of a new dog isolate of canine distemper virus from China. Qiao, J.,Meng, Q.,Chen, C.,Xia, X.,Ren, Y.,Zhang, H.,Qiao, J.,Cai, X.. 2011

[2]Inactivated Recombinant Rabies Viruses Displaying Canine Distemper Virus Glycoproteins Induce Protective Immunity against Both Pathogens. Budaszewski, Renata da Fontoura,Budaszewski, Renata da Fontoura,Sawatsky, Bevan,Kraemer, Beate,von Messling, Veronika,Sawatsky, Bevan,von Messling, Veronika,Hudacek, Andrew,Yin, Xiangping,Schnell, Matthias J.,Yin, Xiangping.

[3]Sequence analysis of the haemagglutinin genes of H9N2 avian influenza viruses isolated in China during 1996 to 2011. Dai, Yin,Zhao, Ruihong,Hu, Xiaomiao,Zhang, Danjun,Wang, Junjun,Xu, Fazhi. 2012

[4]Sequence and phylogenetic analysis of hemagglutinin genes of H9N2 influenza viruses isolated from chicken in China from 2013 to 2015. Su Xiao-na,Xie Qing-mei,Chen Wei-guo,Bi Ying-zuo,Chen Feng,Su Xiao-na,Xie Qing-mei,Chen Feng,Su Xiao-na,Xie Qing-mei,Chen Feng,Liao Chang-tao,Yan Zhuan-qiang. 2016

[5]Are ducks contributing to the endemicity of highly pathogenic H5N1 influenza virus in Asia?. Sturm-Ramirez, KM,Hulse-Post, DJ,Govorkova, EA,Humberd, J,Seiler, P,Puthavathana, P,Buranathai, C,Nguyen, TD,Chaisingh, A,Long, HT,Naipospos, TSP,Chen, H,Ellis, TM,Guan, Y,Peiris, JSM,Webster, RG.

[6]H9N2 avian influenza virus-derived natural reassortant H5N2 virus in swan containing the hemagglutinin segment from Eurasian H5 avian influenza virus with an in-frame deletion of four basic residues in the polybasic hemagglutinin cleavage site. Wang, Youling,Yuan, Xiaoyuan,Qi, Lihong,Zhang, Yuxia,Xu, Huaiying,Yang, Jinxing,Ai, Wu,Song, Minxun,Li, Feng,Qi, Wenbao,Liao, Ming,Wang, Dan,Li, Feng,Li, Feng.

[7]First report of the molecular detection of Ancylostoma caninum in Lahore, Pakistan: the threat from pets. Rehman, A.,Shehzad, W.,Islam, S.,Bajwa, A. A.,Akhtar, R.,Rashid, I.,Akbar, H.,Riaz, F.,Waqas, M.. 2017

[8]Cloning and Sequence Analysis of N Gene of Transmissible Gastroenteritis Virus HYM-09 Isolated from Dog in China. Yu, Xiaolong,Man, Chaolai. 2012

[9]Comparison of miRNA expression profiles in pituitary-adrenal axis between Beagle and Chinese Field dogs after chronic stress exposure. Luo, Wei,Xu, Haiping,Nie, Qinghua,Luo, Wei,Xu, Haiping,Nie, Qinghua,Luo, Wei,Xu, Haiping,Nie, Qinghua,Luo, Wei,Xu, Haiping,Nie, Qinghua,Fang, Meixia,Xing, Huijie,Fu, Jiangnan. 2016

[10]Prevalence of Toxoplasma gondii in Dogs in Zhanjiang, Southern China. Jiang, Hai-Hai,Li, Ming-Wei,Xu, Min-Jun,Cong, Wei,Zhu, Xing-Quan,Li, Ming-Wei,Cong, Wei,Zhu, Xing-Quan. 2015

[11]A PCR survey of vector-borne pathogens in different dog populations from Turkey. Guo, Huanping,Gao, Yang,Moumouni, Paul Franck Adjou,Liu, Mingming,Efstratiou, Artemis,Wang, Guanbo,Cao, Shinuo,Jirapattharasate, Charoonluk,Ringo, Aaron Edmond,Zheng, Weiqing,Xuan, Xuenan,Sevinc, Ferda,Ceylan, Onur,Sevinc, Mutlu,Ince, Ege,Zhou, Mo.

[12]Seroprevalence survey of Babesia gibsoni infection and tick species in dogs in East China. Cao, Jie,Yang, Qiqing,Zhou, Yongzhi,Zhang, Houshuang,Gong, Haiyan,Zhou, Jinlin,Zhang, Jianwei,Zhou, Jinlin.

[13]Development of a combined canine distemper virus specific RT-PCR protocol for the differentiation of infected and vaccinated animals (DIVA) and genetic characterization of the hemagglutinin gene of seven Chinese strains demonstrated in dogs. Yi, Li,Cheng, Shipeng,Xu, Hongli,Wang, Jianke,Cheng, Yuening,Yang, Shen,Luo, Bin. 2012

[14]Recombinant Newcastle disease viral vector expressing hemagglutinin or fusion of canine distemper virus is safe and immunogenic in minks. Ge, Jinying,Wang, Xijun,Tian, Meijie,Wen, Zhiyuan,Yu, Guimei,Zhou, Weiwei,Zu, Shulong,Bu, Zhigao,Gao, Yuwei.

[15]Identification of a novel canine distemper virus B-cell epitope using a monoclonal antibody against nucleocapsid protein. Yi, Li,Cheng, Yuening,Zhang, Miao,Cao, Zhigang,Tong, Mingwei,Wang, Jianke,Zhao, Hang,Lin, Peng,Cheng, Shipeng.

[16]Isolation and sequence analysis of a canine distemper virus from a raccoon dog in Jilin Province, China. Cheng, Yuening,Wang, Jianke,Zhang, Miao,Zhao, Jianjun,Shao, Xiqun,Zhao, Hang,Lin, Peng,Wu, Hua,Ma, Zengjun.

[17]Pathogenesis of canine distemper virus in experimentally infected raccoon dogs, foxes, and minks. Zhao, Jianjun,Shi, Ning,Sun, Yangang,Zhu, Chunsheng,Zhang, Hailing,Hu, Bo,Bai, Xue,Yan, Xijun,Zhao, Jianjun,Yan, Xijun,Martella, Vito,Nikolin, Veljko.

[18]Identification of a novel linear B-cell epitope using a monoclonal antibody against the carboxy terminus of the canine distemper virus nucleoprotein and sequence analysis of the identified epitope in different CDV isolates. Yi, Li,Cao, Zhigang,Tong, Mingwei,Cheng, Yuening,Li, Shuang,Wang, Jianke,Lin, Peng,Sun, Yaru,Zhang, Miao,Cheng, Shipeng,Yang, Yong. 2017

[19]Phylogenetic analysis of the haemagglutinin gene of canine distemper virus strains detected from breeding foxes, raccoon dogs and minks in China. Zhao, Jian-Jun,Yan, Xi-Jun,Chai, Xiu-Li,Luo, Guo-Liang,Zhang, Hai-Ling,Gao, Han,Bai, Xue,Zhang, Lei,Chen, Tao,Xu, Lei,Zhao, Chun-Fei,Wang, Feng-Xue,Shao, Xi-Qun,Wu, Wei,Cheng, Shi-Peng,Martella, Vito,Liu, Ying-Xue.

[20]Emergence of canine distemper virus strains with two amino acid substitutions in the haemagglutinin protein, detected from vaccinated carnivores in North-Eastern China in 2012-2013. Zhao, Jianjun,Zhang, Hailing,Bai, Xue,Hu, Bo,Sun, Yangang,Zhu, Chunsheng,Zhang, Lei,Liu, Hao,Xu, Shujuan,Shao, Xiqun,Wu, Wei,Yan, Xijun,Zhao, Jianjun,Yan, Xijun,Martella, Vito. 2014

作者其他论文 更多>>

微信小程序