Selective capture of transcribed sequences in the functional gene analysis of microbial pathogens

文献类型： 外文期刊

第一作者： Wang, Yang

作者： Wang, Yang;Wang, Yang;Wang, Shaohui;Ding, Chan;Yi, Li;Yi, Li;Lu, Chengping

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关键词： Selective capture of transcribed sequences;Pathogenic;Bacterium-host interaction;Animal pathogens

期刊名称：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY （ 影响因子：4.813； 五年影响因子：4.697 ）

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收录情况： SCI

摘要： Selective capture of transcribed sequences (SCOTS) is an effective method to identify bacterial genes differentially expressed during different biological processes, including pathogenic interactions with a host species. The method can be used to elucidate molecular mechanisms driving and maintaining such interactions. The method is a powerful genetic tool that overcomes limitations found in other methods, by working with small amounts of mRNA and allowing for the separation of bacterial cDNA from host cDNA. It has been increasingly used in the discovery of genes involved in the bacterium-host interaction. In this review, we briefly introduce the SCOTS method, outline the technical advances offered in the method, and focus on the method's applications in several microbial pathogens.

分类号： Q939.9`Q81

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