Evaluation of insecticidal activity of camptothecin analogs against Brontispa longissima

文献类型： 外文期刊

第一作者： Yang, Liu

作者： Yang, Liu;Zhang, Zhi-Jun;Liu, Ying-Qian;Zhao, Chun-Yan;Wang, Mei-Juan;Nan, Xiang;Feng, Gang

作者机构：

关键词： Camptothecin;Insecticidal activity;Brontispa longissima;Structure-activity relationships

期刊名称：MEDICINAL CHEMISTRY RESEARCH （ 影响因子：1.965； 五年影响因子：1.98 ）

ISSN：

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收录情况： SCI

摘要： Continuing our search for natural product-based compounds for the control of Brontispa longissima Larvae, 31 camptothecin analogs were first tested for their insecticidal activity against the fifth-instar larvae of B. longissima in vivo. Among them, compounds 6-8, 11, 26, 28, and 29 showed more promising and pronounced insecticidal activity than toosendanin, a commercial insecticide derived from Melia azedarach. The different insecticidal activity ranges of compounds 1-31 indicated that variation of chemical structures in the camptothecin skeleton markedly affected the activity profiles of this compound class, and some important SAR information has been revealed from it. The quantitative structure-activity relationship (QSAR) model was applied to provide insight into the camptothecin analogs' structural properties that are responsible for their activities. The results obtained from SAR analysis showed good correlation with the QSAR studies, which allowed for the rational design of more potent camptothecin analogs in the development of potential new insecticides.

分类号： R9

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