Evaluation of insecticidal activity of camptothecin analogs against Brontispa longissima
文献类型: 外文期刊
第一作者: Yang, Liu
作者: Yang, Liu;Zhang, Zhi-Jun;Liu, Ying-Qian;Zhao, Chun-Yan;Wang, Mei-Juan;Nan, Xiang;Feng, Gang
作者机构:
关键词: Camptothecin;Insecticidal activity;Brontispa longissima;Structure-activity relationships
期刊名称:MEDICINAL CHEMISTRY RESEARCH ( 影响因子:1.965; 五年影响因子:1.98 )
ISSN:
年卷期:
页码:
收录情况: SCI
摘要: Continuing our search for natural product-based compounds for the control of Brontispa longissima Larvae, 31 camptothecin analogs were first tested for their insecticidal activity against the fifth-instar larvae of B. longissima in vivo. Among them, compounds 6-8, 11, 26, 28, and 29 showed more promising and pronounced insecticidal activity than toosendanin, a commercial insecticide derived from Melia azedarach. The different insecticidal activity ranges of compounds 1-31 indicated that variation of chemical structures in the camptothecin skeleton markedly affected the activity profiles of this compound class, and some important SAR information has been revealed from it. The quantitative structure-activity relationship (QSAR) model was applied to provide insight into the camptothecin analogs' structural properties that are responsible for their activities. The results obtained from SAR analysis showed good correlation with the QSAR studies, which allowed for the rational design of more potent camptothecin analogs in the development of potential new insecticides.
分类号: R9
- 相关文献
作者其他论文 更多>>
-
Effects of boiling, centrifuging and drying methods on bioactive compounds in Antarctic krill meal
作者:Yang, Liu;Zhang, Shuaishuai;Wang, Xin;Yang, Liu;Zheng, Yao;Zhang, Shuaishuai;Guo, Quanyou;Yang, Liu;Zheng, Yao;Zhang, Shuaishuai;Guo, Quanyou
关键词:Antarctic krill; drying methods; manufacturing process; bioactive compounds
-
IiAGL6 participates in the regulation of stamen development and pollen formation in Isatis indigotica
作者:Yang, Liu;Qiao, Xin;He, Hao-En;Yi, Wei-Wei;Gao, Ya-Nan;Tan, Xiao-Min;Cheng, Hao;Hou, Xiao-Fang;Ma, Ye -Ye;Wang, Hong -Li;Huang, Xuan;Ma, Yan-Qin;Xu, Zi-Qin;Ma, Yan-Qin
关键词:AGMOUSE LIKE 6; Arabidopsis thaliana; Isatis indigotica fortune; Development of stamen; Virus-induced gene silencing
-
Prevention of the Quality Degradation of Antarctic Krill (Euphausia superba) Meal through Two-Stage Drying
作者:Zheng, Yao;Zhang, Shuaishuai;Yang, Liu;Wei, Banghong;Guo, Quanyou;Zheng, Yao;Guo, Quanyou;Zhang, Shuaishuai;Yang, Liu
关键词:krill meal; two-stage drying; hot-air drying; vacuum drying; bioactive compounds
-
Selecting appropriate forage cover crops to improve growth, yield, and fruit quality of wolfberry by regulation of photosynthesis and biotic stress resistance
作者:Wang, Fang;Chen, Haonan;Wang, Fang;Zhu, Lizhen;Nan, Xiongxiong;Yang, Liu;Jia, Qiaoxia;Yu, Zelong;Zhu, Lizhen;Nan, Xiongxiong;Yang, Liu;Jia, Qiaoxia;Yu, Zelong;He, Jun;Wang, Hao;Zhao, Yan;Yan, Huiqin
关键词:Forage species; Photosynthesis enhancement; Wolfberry growth; Plant diseases; Pests
-
Effect of SHAM on the activity of coumoxystrobin against Phytophthora litchii
作者:Jing, Suyue;Zhu, Fadi;Wen, Xiaodong;Zhang, Jing;Feng, Gang;Zhu, Fadi;Zhang, Jing;Feng, Gang
关键词:Litchi downy blight; Inhibition effect; Developmental stages; Oxygen consumption
-
Antibacterial Activity and Possibly Made of Action of Isoquinoline-3-Carboxylic Acid
作者:Xu, Zhiyuan;Fu, Xin;Xu, Yan;Zhu, Fadi;Ye, Huochun;Zhang, Yuan Yuan;Zhang, Jing;Feng, Gang;Ding, Haixin;Fu, Xin;Zhang, Yuan Yuan;Guo, Yongxia
关键词:isoquinoline-3-carboxylic acid; antibacterial activity; Acidovorax citrulli
-
A compendium of genetic regulatory effects across pig tissues
作者:Teng, Jinyan;Gao, Yahui;Xu, Zhiting;Lin, Qing;Diao, Shuqi;Pan, Xiangchun;Wei, Chen;Zhang, Zhe;Zhang, Zhe;Gao, Yahui;Li, Cong-jun;Liu, George E.;Gao, Yahui;Gao, Yahui;Yin, Hongwei;Bai, Lijing;Yang, Liu;Yi, Guoqiang;Tang, Zhonglin;Li, Kui;Yin, Hongwei;Bai, Zhonghao;Bai, Zhonghao;Yu, Xiaoshan;Haley, Chris;Navarro, Pau;Tenesa, Albert;Fang, Lingzhao;Liu, Shuli;Zhao, Bingru;Yang, Wenjing;Ding, Xiangdong;Li, Xiujin;Pan, Zhangyuan;Yang, Wenjing;Guan, Dailu;Pan, Zhangyuan;Hou, Yali;Hou, Yali;Keel, Brittney N.;Rohrer, Gary A.;Lindholm-Perry, Amanda K.;Oliver, William T.;Ballester, Maria;Crespo-Piazuelo, Daniel;Quintanilla, Raquel;Rawlik, Konrad;Xia, Charley;Xia, Charley;Yao, Yuelin;Yao, Wenye;Karlskov-Mortensen, Peter;Fredholm, Merete;Amills, Marcel;Clop, Alex;Amills, Marcel;Godia, Marta;Clop, Alex;Giuffra, Elisabetta;Rocha, Dominique;Wang, Sheng;Rocha, Dominique;Dekkers, Jack C. M.;Kramer, Luke;Tuggle, Christopher K.;Corbett, Ryan;Charles, Mathieu;Pausch, Hubert;Hu, Xiaoxiang;Frantz, Laurent;Frantz, Laurent;Luo, Yonglun;Lin, Lin;Luo, Yonglun;Lin, Lin;Luo, Yonglun;Zhang, Zhe;Chen, Zitao;Cui, Leilei;Cui, Leilei;Cui, Leilei;Cui, Leilei;Cui, Leilei;Xiang, Ruidong;Xiang, Ruidong;Shen, Xia;Shen, Xia;Shen, Xia;Li, Pinghua;Huang, Ruihua;Tang, Guoqing;Li, Mingzhou;Zhao, Yunxiang;Jiang, Jicai;Yuan, Xiaolong;Liu, Xiaohong;Zhao, Shuhong;Zhao, Pengju;Zhao, Shuhong;Zhao, Pengju;Zhao, Pengju;Haley, Chris;Tenesa, Albert;Zhang, Qin;Tenesa, Albert
关键词: