A genome-wide SNP scan in a porcine Large White x Minzhu intercross population reveals a locus influencing muscle mass on chromosome 2

文献类型： 外文期刊

第一作者： Liu, Xin

作者： Liu, Xin;Wang, Li Gang;Liang, Jing;Yan, Hua;Zhao, Ke Bin;Wang, Li Xian;Zhang, Long Chao;Luo, Wei Zhen;Li, Yong

作者机构：

关键词： genome-wide association study;lean meat in ham;lean meat percentage;pig

期刊名称：ANIMAL SCIENCE JOURNAL （ 影响因子：1.749； 五年影响因子：1.909 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： A high-density single nucleotide polymorphism (SNP) array containing 62163 markers was employed for a genome-wide association study (GWAS) to identify variants associated with lean meat in ham (LMH, %) and lean meat percentage (LMP, %) within a porcine Large WhitexMinzhu intercross population. For each individual, LMH and LMP were measured after slaughter at the age of 240 +/- 7 days. A total of 557 F2 animals were genotyped. The GWAS revealed that 21 SNPs showed significant genome-wide or chromosome-wide associations with LMH and LMP by the Genome-wide Rapid Association using Mixed Model and Regression-Genomic Control approach. Nineteen significant genome-wide SNPs were mapped to the distal end of Sus Scrofa Chromosome (SSC) 2, where a major known gene responsible for muscle mass, IGF2 is located. A conditioned analysis, in which the genotype of the strongest associated SNP is included as a fixed effect in the model, showed that those significant SNPs on SSC2 were derived from a single quantitative trait locus. The two chromosome-wide association SNPs on SSC1 disappeared after conditioned analysis suggested the association signal is a false association derived from using a F2 population. The present result is expected to lead to novel insights into muscle mass in different pig breeds and lays a preliminary foundation for follow-up studies for identification of causal mutations for subsequent application in marker-assisted selection programs for improving muscle mass in pigs.

分类号： S8

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