Muscovy duck retinoic acid-induced gene I (MdRIG-I) functions in innate immunity against H9N2 avian influenza viruses (AIV) infections
文献类型: 外文期刊
第一作者: Cheng, Yuqiang
作者: Cheng, Yuqiang;Huang, Qingqing;Ji, Wenhui;Du, Bin;Fu, Qiang;An, Huiting;Wang, Hengan;Yan, Yaxian;Ding, Chan;Sun, Jianhe;Ding, Chan;Li, Jing
作者机构:
关键词: Muscovy duck;RIG-I;IFN-beta;Innate immune response;DF-1;H9N2
期刊名称:VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY ( 影响因子:2.046; 五年影响因子:2.217 )
ISSN:
年卷期:
页码:
收录情况: SCI
摘要: Retinoic acid inducible gene I (RIG-I) is a cytosolic pattern recognition receptor that senses pathogen-associated molecular patterns (PAMPs). Muscovy duck (Cairina moschata) is a large duck different from other species of ducks, and is more susceptible to some microbial pathogens. In this study, the Muscovy duck RIG-I gene (MdRIG-I) was identified. Quantitative RT-PCR showed that MdRIG-I mRNA was widely expressed in different tissues, especially in those with mucosa. RIG-I null DF-1 cells transfected with DNA constructs encoding MdRIG-I or CARDs domain can activate IRF-3 and NF-kappa B to up-regulated activity of IFN-beta promoter. The components of the signaling pathway downstream of RIG-I in mammalian cells including IRF-3, NF-kappa B, IFN-beta and the IFN-stimulated genes Mx-1, PKR and MDA5 were significantly up-regulated in CARD5-overexpressing-DF-1 cells. Implicating RIG-I in the antiviral response to an infection in vivo, we found that RIG-I expression in brain, spleen, lung and bursa were up-regulated in ducks challenged with H9N2 avian influenza virus (AIV), whose six internal genes were closely related to the H7N9 and H10N8 AIV. In vitro, DF-1 cells transfected with MdRIG-I plasmid can respond significantly to H9N2 AIV, evident through enhancement of IFN-beta promoter activity and decreased virus titer. Altogether, these results indicated that MdRIG-I is a novel member of RLR gene family, engaging in the early stage of antiviral innate immunity. (C) 2014 Elsevier B.V. All rights reserved.
分类号: S85
- 相关文献
作者其他论文 更多>>
-
A novel Brucella T4SS effector RS15060 acts on bacterial morphology, lipopolysaccharide core synthesis and host proinflammatory responses, which is beneficial for Brucella melitensis virulence
作者:Yin, Yi;Tian, Mingxing;Zhang, Guangdong;Ding, Chan;Yu, Shengqing;Ding, Chan;Yu, Shengqing
关键词:Brucella; RS15060; Bacterial morphology; Lipopolysaccharide; Virulence
-
Rice-Potato Rotation Pattern Affects 2-Acetyl-1-Pyrroline Biosynthesis and Productivity in Aromatic Rice Grains
作者:Hu, Fengqin;Shen, Congcong;Feng, Dehao;Zhu, Shuangbing;Zhu, Jianqiang;Qiu, Xianjin;Du, Bin;Hu, Fengqin;Xu, Jianlong;Shen, Congcong;Zhu, Shuangbing;Chen, Kai;Xu, Jianlong;Lu, Jian;Du, Bin;Xu, Jianlong
关键词:aromatic rice; rice-potato rotation; 2-acetyl-1-pyrroline; rice quality
-
Copy Number Variations in Short Tandem Repeats Modulate Growth Traits in Penaeid Shrimp Through Neighboring Gene Regulation
作者:Zhou, Hao;Qiang, Guangfeng;Xia, Yan;Tan, Jian;Fu, Qiang;Luo, Kun;Meng, Xianhong;Chen, Baolong;Chen, Meijia;Sui, Juan;Dai, Ping;Li, Xupeng;Liu, Mianyu;Kong, Jie;Luan, Sheng;Zhou, Hao;Qiang, Guangfeng;Xia, Yan;Tan, Jian;Fu, Qiang;Luo, Kun;Meng, Xianhong;Chen, Baolong;Chen, Meijia;Sui, Juan;Dai, Ping;Li, Xupeng;Liu, Mianyu;Kong, Jie;Luan, Sheng;Xing, Qun
关键词:short tandem repeats; STR; growth trait; penaeid shrimp; molecular breeding
-
Genetic Diversity Assessment and Core Germplasm Screening of Blackcurrant (Ribes nigrum) in China via Expressed Sequence Tag-Simple Sequence Repeat Markers
作者:Sun, Xinyu;Fu, Qiang;Qin, Dong;Xiong, Jinyu;Quan, Xin;Guo, Hao;Huo, Junwei;Zhu, Chenqiao;Tang, Jiahan
关键词:
Ribes nigrum ; EST-SSR markers; genetic diversity; population structure; core germplasm resources -
Metabolomic and Transcriptomic Analyses of Flavonoid Biosynthesis in Different Colors of Soybean Seed Coats
作者:Fan, Yuanfang;Wang, Xianshu;Yang, Mei;Zhong, Xiaojuan;Zhou, Yonghang;Xiang, Chao;Fan, Yuanfang;Wang, Xianshu;Yang, Mei;Zhong, Xiaojuan;Zhou, Yonghang;Xiang, Chao;Hussain, Sajad;Tao, Lei;Li, Jing
关键词:soybean; flavonoid; transcriptome; metabolome; seed coat color
-
Evaluating Sustainable Development in the Middle and Lower Reaches of the Yellow River Basin Using Multiple Data Sources
作者:Lu, Yuefeng;Li, Jing;Song, Zhenqi;Lu, Yuefeng;Lu, Miao;Lu, Yuefeng;Lu, Miao
关键词:Rivers; Indexes; Sustainable development; Socioeconomics; Remote sensing; Water resources; Urban areas; Soil; Biological system modeling; Surface treatment; Ecological environment; influencing factors; middle and lower reaches of the Yellow River Basin; social economy; sustainable development
-
Soil microbiome mediates plant community productivity in grass-legume mixtures
作者:Li, Jing;Zhang, Wenbo;Yang, Xiaojiang;Jiang, Shenyi;Wang, Zhen;Jin, Ke;Li, Jing;Xu, Zhuwen;Yang, Xiaojiang;Jiang, Shenyi;Struik, Paul C.
关键词:Grass-legume ratios; Symbiosis; Mycorrhizal fungi; Nitrogen-fixing bacteria; Plant productivity