Quantification of aflatoxin M1 in raw milk by a core-shell column on a conventional HPLC with large volume injection and step gradient elution

文献类型： 外文期刊

第一作者： Lei, Shaorong

作者： Lei, Shaorong;Liu, Yunhua;Fu, Chengping;Zhong, Lingli;Ouyang, Huaxue;Mao, Jianfei;Lei, Shaorong;Fu, Chengping;Zhong, Lingli;Ouyang, Huaxue;Xiao, Dan;Xiao, Dan

作者机构：

关键词： HPLC-FLD;Aflatoxin M1;lmmunoaffinity column cleanup;Core-shell column;Step gradient elution;Raw milk

期刊名称：FOOD CONTROL （ 影响因子：5.548； 五年影响因子：5.498 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： The immunoaffinity column cleanup method coupled with HPLC separation and fluorescence detection is still one of the most frequently used quantitative methods for routine analyses of AFM1. In this study, aflatoxin M1 (AFM1) was quantified with a chromatography column packed with 2.6 gm core-shell particles on a conventional HPLC. A large volume of solvent (100 mu L) was injected into the highly efficient column without any noticeable reduction in separation performance with the help of stepwise gradient elution. The instrumental conditions were optimized by response surface analysis methodology (RSM) with a three-level three-factor Box-Behnken design.

分类号： TS2

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