Comparative genomic analysis of aspartic proteases in eight parasitic platyhelminths: Insights into functions and evolution

文献类型： 外文期刊

第一作者： Wang, Shuai

作者： Wang, Shuai;Wei, Wei;Luo, Xuenong;Cai, Xuepeng;Wang, Sen;Hu, Songnian

作者机构：

关键词： Aspartic protease;Platyhelminth;Gene loss;Gene expansion;Drug target

期刊名称：GENE （ 影响因子：3.688； 五年影响因子：3.329 ）

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收录情况： SCI

摘要： We performed genome-wide identifications and comparative genomic analyses of the predicted aspartic proteases (APs) from eight parasitic flatworms, focusing on their evolution, potentials as drug targets and expression patterns. The results revealed that: i) More members of family A01 were identified from the schistosomes than from the cestodes; some evidence implied gene loss events along the class Cestoda, which may be related to the different ways to ingest host nutrition; ii) members in family A22 were evolutionarily highly conserved among all the parasites; iii) one retroviral-like AP in family A28 shared a highly similar predicted 3D structure with the HIV protease, implying its potential to be inhibited by HIV inhibitor-like molecules; and iiii) retrotransposon-associated APs were extensively expanded among these parasites. These results implied that the evolutionary histories of some APs in these parasites might relate to adaptations to their parasitism and some APs might have potential serving as intervention targets. (C) 2015 Elsevier B.V. All rights reserved.

分类号： R394

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