Lethal infection by a novel reassortant H5N1 avian influenza A virus in a zoo-housed tiger

文献类型： 外文期刊

第一作者： He, Shang

作者： He, Shang;Huang, Guoqing;Lu, Chengping;He, Shang;Lu, Chengping;He, Shang;Lu, Chengping;Shi, Jianzhong;Chen, Hualan;Qi, Xian

作者机构：

关键词： Novel reassortant avian influenza A virus;H5N1;Tiger

期刊名称：MICROBES AND INFECTION （ 影响因子：2.7； 五年影响因子：3.143 ）

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收录情况： SCI

摘要： In early 2013, a Bengal tiger (Panthera tigris) in a zoo died of respiratory distress. All specimens from the tiger were positive for HPAI H5N1, which were detected by real-time PCR, including nose swab, throat swab, tracheal swab, heart, liver, spleen, lung, kidney, aquae pericardii and cerebrospinal fluid. One stain of virus, A/Tiger/JS/1/2013, was isolated from the lung sample. Pathogenicity experiments showed that the isolate was able to replicate and cause death in mice. Phylogenetic analysis indicated that HA and NA of A/Tiger/JS/1/2013 clustered with A/ duck/Vietnam/OIE-2202/2012 (H5N1), which belongs to clade 2.3.2.1. Interestingly, the gene segment PB2 shared 98% homology with A/wild duck/Korea/CSM-28/20/2010 (H4N6), which suggested that A/Tiger/JS/1/2013 is a novel reassortant H5N1 subtype virus. Immunohistochemical analysis also confirmed that the tiger was infected by this new reassortant HPAI H5N1 virus. Overall, our results showed that this Bengal tiger was infected by a novel reassortant H5N1, suggesting that the H5N1 virus can successfully cross species barriers from avian to mammal through reassortment. (C) 2014 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

分类号： Q2

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