Multidrug resistance genes in staphylococci from animals that confer resistance to critically and highly important antimicrobial agents in human medicine

文献类型: 外文期刊

第一作者: Wendlandt, Sarah

作者: Wendlandt, Sarah;Kadlec, Kristina;Fessler, Andrea T.;Schwarz, Stefan;Shen, Jianzhong;Wang, Yang;Wu, Congming;Li, Beibei;Zhang, Wan-Jiang

作者机构:

关键词: antimicrobial resistance;plasmid;transposon;colocation;coselection;cotransfer

期刊名称:TRENDS IN MICROBIOLOGY ( 影响因子:17.079; 五年影响因子:18.337 )

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收录情况: SCI

摘要: Most antimicrobial resistance genes known so far to occur in staphylococci of animal origin confer resistance to a specific class of antimicrobial agents or to selected members within such a class. However, there are also a few examples of multidrug resistance (MDR) genes that confer resistance to antimicrobial agents of different classes by either target site methylation or active efflux via ATP-binding cassette (ABC) transporters. The present review provides an overview of these MDR genes with particular reference to those genes involved in resistance to critically or highly important antimicrobial agents used in human and veterinary medicine. Moreover, their location on mobile genetic elements and colocated resistance genes, which may play a role in coselection and persistence of the MDR genes, are addressed.

分类号: Q93

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