Toxoplasma gondii infection in cancer patients: Prevalence, risk factors, genotypes and association with clinical diagnosis

文献类型： 外文期刊

第一作者： Cong, Wei

作者： Cong, Wei;Liu, Guo-Hua;Qin, Si-Yuan;Zhang, Fu-Kai;Zhu, Xing-Quan;Cong, Wei;Qin, Si-Yuan;Qian, Ai-Dong;Zhu, Xing-Quan;Meng, Qing-Feng;Dong, Wei;Zhang, Xiang-Yan;Wang, Xiang-Yang

作者机构：

关键词： Toxoplasma gondii;Cancer patients;Prevalence;Risk factors;Genotype

期刊名称：CANCER LETTERS （ 影响因子：8.679； 五年影响因子：8.64 ）

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收录情况： SCI

摘要： Prevalence of human infection with Toxoplasma gondii has been increasing in China due to the increasing number of cats. However, little is known of the epidemiology of T. gondii infection in different cancer patient groups. Thus, a case-control study of 900 cancer patients and 900 controls was conducted to detect anti-T. gondii antibodies by ELISA in China. Genomic DNA was extracted from the diseased tissues of 510 patients and the T. gondii B1 gene was amplified using a semi-nested PCR. DNA samples giving positive B1 amplification were then genetically characterized using multi-locus PCR-RFLP. The prevalence of anti-T. gondii IgG in cancer patients (35.56%) was significantly higher than that in controls (17.44%). The highest T. gondii seroprevalence was detected in lung cancer patients (60.94%), followed by cervical cancer patients (50%), brain cancer patients (42.31%) and endometrial cancer patients (41.67%). Exposure with soil and consumption of raw/undercooked meat were significantly associated with T. gondii infection in cancer patients. Three T. gondii genotypes (ToxoDB#9, ToxoDB#10 and Type I variant) were identified. In conclusion, T gondii infection is a severe problem in cancer patients and it is imperative that improved integrated measures should be conducted to prevent and control T gondii infection in cancer patients. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

分类号： R73

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