Toxoplasma gondii infection in cancer patients: Prevalence, risk factors, genotypes and association with clinical diagnosis

文献类型： 外文期刊

第一作者： Cong, Wei

作者： Cong, Wei;Liu, Guo-Hua;Qin, Si-Yuan;Zhang, Fu-Kai;Zhu, Xing-Quan;Cong, Wei;Qin, Si-Yuan;Qian, Ai-Dong;Zhu, Xing-Quan;Meng, Qing-Feng;Dong, Wei;Zhang, Xiang-Yan;Wang, Xiang-Yang

作者机构：

关键词： Toxoplasma gondii;Cancer patients;Prevalence;Risk factors;Genotype

期刊名称：CANCER LETTERS （ 影响因子：8.679； 五年影响因子：8.64 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Prevalence of human infection with Toxoplasma gondii has been increasing in China due to the increasing number of cats. However, little is known of the epidemiology of T. gondii infection in different cancer patient groups. Thus, a case-control study of 900 cancer patients and 900 controls was conducted to detect anti-T. gondii antibodies by ELISA in China. Genomic DNA was extracted from the diseased tissues of 510 patients and the T. gondii B1 gene was amplified using a semi-nested PCR. DNA samples giving positive B1 amplification were then genetically characterized using multi-locus PCR-RFLP. The prevalence of anti-T. gondii IgG in cancer patients (35.56%) was significantly higher than that in controls (17.44%). The highest T. gondii seroprevalence was detected in lung cancer patients (60.94%), followed by cervical cancer patients (50%), brain cancer patients (42.31%) and endometrial cancer patients (41.67%). Exposure with soil and consumption of raw/undercooked meat were significantly associated with T. gondii infection in cancer patients. Three T. gondii genotypes (ToxoDB#9, ToxoDB#10 and Type I variant) were identified. In conclusion, T gondii infection is a severe problem in cancer patients and it is imperative that improved integrated measures should be conducted to prevent and control T gondii infection in cancer patients. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

分类号： R73

  • 相关文献

[1]Toxoplasma gondii Infection in Immunocompromised Patients: A Systematic Review and Meta-Analysis. Wang, Ze-Dong,Wei, Feng,Wang, Ze-Dong,Zhu, Xing-Quan,Wang, Ze-Dong,Liu, Huan-Huan,Ma, Hong-Yu,Li, Zhong-Yu,Liu, Quan,Ma, Zhan-Xi,Yang, Zhi-Bin,Xu, Bin,Liu, Quan. 2017

[2]Seroprevalence, risk factors and genetic characterization of Toxoplasma gondii in free-range white yaks (Bos grunniens) in China. Qin, S. Y.,Zhou, D. H.,Cong, W.,Zhang, X. X.,Lou, Z. L.,Yin, M. Y.,Tan, Q. D.,Zhu, X. Q.,Qin, S. Y.,Cong, W.,Zhang, X. X.,Lou, Z. L.,Zhu, X. Q.,Yin, M. Y.,Tan, Q. D..

[3]Seroprevalence, risk factors and genotyping of Toxoplasma gondii in domestic geese (Anser domestica) in tropical China. Rong, Guang,Zhou, Han-Lin,Hou, Guan-Yu,Xu, Tie-Shan,Guan, Song,Zhao, Jun-Ming. 2014

[4]Seroprevalence of Toxoplasma gondii infection in arthritis patients in eastern China. Tian, Ai-Ling,Cong, Wei,Li, Guang-Xing,Zhu, Xing-Quan,Gu, Yuan-Lin,Zhou, Na,Li, Guang-Xing,Elsheikha, Hany M.. 2017

[5]Seroepidemiological study of canine Leishmania infantum and Toxoplasma gondii infections in Shanghai, China, and analysis of risk factors. Jiang, Wei,Liu, Yingchun,Li, Tao,Chen, Yongjun,Wang, Shaohui,Han, Xiangan,Wang, Quan,Wang, Yan. 2016

[6]Toxoplasma gondii Infection in Farmed Wild Boars (Sus scrofa) in Three Cities of Northeast China. Bai, Meng-Jie,Zou, Yang,Ma, Jian-Gang,Zheng, Wen-Bin,Zhang, Xiao-Xuan,Zhu, Xing-Quan,Zou, Yang,Ma, Jian-Gang,Zheng, Wen-Bin,Zhao, Quan,Zhang, Xiao-Xuan,Elsheikha, Hany M.,Zhu, Xing-Quan. 2017

[7]Seroepidemiology of Toxoplasma gondii infection in patients with liver disease in eastern China. Tian, A. L.,Li, G. X.,Cong, W.,Zhu, X. Q.,Li, G. X.,Li, H. L.,Elsheikha, H. M.,Gardner, D. S.,Zhang, X. Y.,Dong, W.,Yang, X. P.,Luo, Y. Y.. 2017

[8]Stray dogs as indicators of Toxoplasma gondii distributed in the environment: the first report across an urban-rural gradient in China. Yan, Chao,Yue, Cai-Ling,Wang, Dong-Hui,Zhou, Dong-Hui,Yan, Chao,Fu, Lin-Lin,Yue, Cai-Ling,Tang, Ren-Xian,Liu, Yi-Sheng,Zhang, Peng,Wang, Dong-Hui,Zheng, Kui-Yang,Lv, Liang,Shi, Na,Zeng, Ping,Zhu, Xing-Quan,Zhu, Xing-Quan. 2012

[9]Prevalence and genetic characterization of Toxoplasma gondii infection in bats in southern China. Jiang, H. H.,Qin, S. Y.,Liu, Q.,Zhu, X. Q.,Wang, W.,He, B.,Tu, C. C.,Liu, Q.,Hu, T. S.,Fan, Q. S.,Wu, J. M.,Qin, S. Y.,Zhu, X. Q..

[10]Prevalence of Toxoplasma gondii in Dogs in Zhanjiang, Southern China. Jiang, Hai-Hai,Li, Ming-Wei,Xu, Min-Jun,Cong, Wei,Zhu, Xing-Quan,Li, Ming-Wei,Cong, Wei,Zhu, Xing-Quan. 2015

[11]Molecular detection and genotypic characterization of Toxoplasma gondii infection in bats in four provinces of China. Qin, Si-Yuan,Cong, Wei,Zhang, Fu-Kai,Huang, Si-Yang,Zhu, Xing-Quan,Liu, Ye,Li, Nan,Wang, Ze-Dong,Liu, Quan,Qin, Si-Yuan,Cong, Wei,Zhu, Xing-Quan,Zhu, Xing-Quan. 2014

[12]Prevalence and genotyping of Toxoplasma gondii in naturally-infected synanthropic rats (Rattus norvegicus) and mice (Mus musculus) in eastern China. Yan, Chao,Liang, Li-Jun,Zhang, Bei-Bei,Zhang, Hui-Feng,Shen, Xuan,Wu, Yu-Qing,Wang, Zi-Mu,Tang, Ren-Xian,Fu, Lin-Lin,Zheng, Kui-Yang,Liang, Li-Jun,Zhang, Hui-Feng,Shen, Xuan,Wang, Zi-Mu,Lou, Zhi-Long,Wu, Yu-Qing. 2014

[13]Prevalence of Toxoplasma gondii antibodies, circulating antigens and DNA in stray cats in Shanghai, China. Wang, Quan,Jiang, Wei,Chen, Yong-Jun,Liu, Chun-Ying,Shi, Jin-lei,Li, Xin-tong. 2012

[14]Prevalence and genetic characterization of Toxoplasma gondii in donkeys in northeastern China. Zhang, Xiao-Xuan,Shi, Kun,Li, Jian-Ming,Du, Rui,Zhang, Nian-Zhang,Zhang, Xiao-Xuan,Zhao, Quan,Shi, Wei,Xu, Peng. 2017

[15]Seroprevalence and genetic characterization of Toxoplasma gondii in masked palm civet (Paguma larvata) in Hainan province, tropical China. Hou, Guan-Yu,Zhou, Han-Lin,Rong, Guang,Zhao, Jun-Ming. 2016

[16]Seroprevalence, Isolation, Genotyping, and Pathogenicity of Toxoplasma gondii Strains from Sheep in China. Yang, YuRong,Feng, YongJie,Lu, YaoYao,Liang, HongDe,Zhang, LongXian,Yao, QiuXia,Zhu, XingQuan,Wang, YingHua. 2017

[17]Antibody Detection, Isolation, Genotyping, and Virulence of Toxoplasma gondii in Captive Felids from China. Yang, Yu-Rong,Feng, Yong-Jie,Lu, Yao-Yao,Dong, Hui,Jiang, Yi-Bao,Zhang, Long-Xian,Li, Tong-Yi,Zhu, Xing-Quan. 2017

[18]Prevalence and genetic characterization of Toxoplasma gondii in badgers (Melogale moschata) in southern China by PCR-RFLP. Kai, Chen,Si-Yang, Huang,Jin-Lei, Wang,Qiu-Xia, Yao,Xing-Quan, Zhu,Si-Yang, Huang,Qiu-Xia, Yao,Xing-Quan, Zhu,Rong-Liang, Hu,Shou-Feng, Zhang,Quan, Liu.

[19]Seroprevalence and genotypes of Toxoplasma gondii isolated from pigs intended for human consumption in Liaoning province, northeastern China. Wang, Dawei,Zhang, Guoxin,Yuan, Gaoming,He, Jianbin,Yang, Na,Liu, Yan,Jiang, Tiantian,Su, Chunlei. 2016

[20]Genetic characterization of Toxoplasma gondii in Yunnan black goats (Capra hircus) in southwest China by PCR-RFLP. Miao, Qiang,Yu, Xin,Yang, Yan,Yang, Jian-Fa,Zhu, Xing-Quan,Zou, Feng-Cai,Miao, Qiang,Huang, Si-Yang,Qin, Si-Yuan,Zhu, Xing-Quan,Qin, Si-Yuan. 2015

作者其他论文 更多>>
  • Efficient Triple Attention and AttentionMix: A Novel Network for Fine-Grained Crop Disease Classification

    作者：Zhang, Yanqi;Zhang, Ning;Chai, Xiujuan;Zhu, Jingbo;Dong, Wei;Sun, Tan

    关键词：crop pests and diseases; CNNs; channel attention; spatial attention; data augmentation

  • AP2X-8 Is Important for Tachyzoite Growth and Bradyzoite Differentiation of Toxoplasma gondii

    作者：Sun, Li-Xiu;Liu, Guo-Hua;Sun, Li-Xiu;Wang, Meng;Xie, Shi-Chen;Fu, Bao-Quan;Elsheikha, Hany M.;Zhu, Xing-Quan

    关键词：Toxoplasma gondii; toxoplasmosis; AP2 transcription factors; AP2X-8; tachyzoite growth; bradyzoite differentiation

  • Assessment of recombinant Lactobacillus vector-based expressing IFITM3 protein anti-PRV infection in mice.

    作者：Zheng, Fan;Zhu, Maokun;Ran, Hengdong;Bai, Binghan;Feng, Simeng;Dong, Wei;Yuan, Xiaomin;He, Jiayi;Li, Bin;Wen, Lixin

    关键词：Recombinant lactic acid bacteria; Interferon-induced transmembrane protein 3; Pseudorabies virus; Antiviral

  • Construction of a Multi-Source, Heterogeneous Rice Disease and Pest Knowledge Graph Based on the MARBC Model

    作者：Li, Chunchun;Yang, Siyi;Liang, Dong;Chen, Peng;Li, Chunchun;Liang, Dong;Chen, Peng;Dong, Wei

    关键词：RDP; MARBC; multi-source heterogeneous; knowledge graph; ontology

  • Genome-Wide Analysis of the APETALA2/Ethylene-Responsive Factor Gene Family in Carthamus tinctorius L.

    作者：Tan, Zheng-Wei;Lu, Dan-Dan;Yu, Yong-Liang;Li, Lei;Xu, Lan-Jie;Dong, Wei;Li, Chun-Ming;Yang, Qing;Liang, Hui-Zhen

    关键词：APETALA2/ethylene-responsive factor; Carthamus tinctorius L; expression pattern; multiple sequence alignment; transcription factor

  • Integrated metabolomic and transcriptomic analyses reveal anthocyanin biosynthesis mechanisms and the regulatory role of LjAN2 in Lonicera japonica

    作者：Tan, Zhengwei;Lu, Dandan;Li, Lei;Yu, Yongliang;Su, Xiaoyu;Sun, Yao;Cao, Yiwen;Li, Chunming;Dong, Wei;Yang, Hongqi;Yang, Qing;An, Sufang;Liang, Huizhen;Tan, Zhengwei;Lu, Dandan;Li, Lei;Yu, Yongliang;Su, Xiaoyu;Sun, Yao;Cao, Yiwen;Li, Chunming;Dong, Wei;Yang, Hongqi;Yang, Qing;An, Sufang;Liang, Huizhen

    关键词：Lonicera japonica; Flower pigmentation; Anthocyanins composition; Anthocyanin synthase; Transcription factors; MYB

  • Fungal diversity notes 1919-2016: taxonomic and phylogenetic contributions to fungal taxa

    作者：Cao, Bin;Wang, Long;Li, Jia-Xin;Han, Xi-Xi;Yang, Wen-Qiang;Wang, Shi-Hui;He, Mao-Qiang;Zhao, Rui-Lin;Cao, Bin;Phurbu, Dorji;Zhao, Rui-Lin;Ralaiveloarisoa, Anna;Liimatainen, Kare;Niskanen, Tuula;Liimatainen, Kare;Niskanen, Tuula;Ramirez-Cruz, Virginia;Cortes-Perez, Alonso;Guzman-Davalos, Laura;Castro-Jauregui, Oscar;Bradshaw, Alexander James;Dentinger, Bryn T. M.;Dentinger, Bryn T. M.;Ramirez-Guillen, Florencia;Villalobos-Arambula, Alma Rosa;da Silva, Paula Santos;Day, Rory;Davoodian, Naveed;Lebel, Teresa;May, Tom W.;Lebel, Teresa;Castellano, Michael;Toome, Merje;Vasey, Jack;Hofer, Katharina;Thangavel, Rajaram;Braithwaite, Mark;Braithwaite, Lewis;Dutta, Arun Kumar;Chattopadhyay, Pinaki;Roy, Niranjan;Tanti, Bhaben;Biswas, Pinky Rani;Roy, Niranjan;Arumugam, Elangovan;Kezo, Kezhocuyi;Kaliyaperumal, Malarvizhi;Murugadoss, Ramesh;Ji, Jing-Xin;Kakishima, Makoto;Cooper, Jerry;Nuytinck, Jorinde;Lagaet, Phaedra;De Lange, Ruben;Verbeken, Annemieke;Tondeleir, Lowie;Nuytinck, Jorinde;Luo, Zong-Long;Wang, Wen-Peng;Zhang, Xian;Li, Hua;Xiong, Yin-Ru;Wu, Na;Shu, Yong-Xin;Zhao, Hai-Jun;Liao, Chun-Fang;Yang, Hong-De;Jayawardena, Ruvishika Shehali;Thongklang, Naritsada;Han, Xi-Xi;Hyde, Kevin D.;Zhang, Xian;Wen, Ting-Chi;Zhang, Xian;Wen, Ting-Chi;Jia, Ao-Li;Fan, Xin-Lei;Jiang, Ning;Jiao, Ning;Zhang, Ying;Manawasinghe, Ishara S.;Li, Hua;Xiong, Yin-Ru;Zhou, Tao;Tan, Qing-Ling;Li, Hua;Xiong, Yin-Ru;Wu, Na;Shu, Yong-Xin;Zhao, Hai-Jun;Liao, Chun-Fang;Yang, Hong-De;Jayawardena, Ruvishika Shehali;Thongklang, Naritsada;Han, Xi-Xi;Hoshino, Tamotsu;Hoshino, Tamotsu;Manz, Cathrin;Hampe, Felix;Zhao, Chang-Lin;Yang, Yang;Zhang, Gui-Qing;Dai, Dong-Qin;Tomsovsky, Michal;Denchev, Teodor T.;Denchev, Cvetomir M.;Denchev, Teodor T.;Denchev, Cvetomir M.;Kemler, Martin;Leveille-Bourret, Etienne;Kemler, Martin;Chen, Yan-Peng;Maharachchikumbura, Sajeewa S. N.;Liu, Jian-Kui;Du, Hong-Zhi;Wu, Na;Feng, Zi-Xuan;Wang, Qi-Ming;Wan, Shan-Ping;Yu, Fu-Qiang;Yu, Fu-Qiang;Du, Hong-Zhi;Du, Hong-Zhi;Hu, Hong-Li;Su, Ji-Yu;Wang, Zong-Hua;Hu, Yan-Ping;Yu, Hao;Wang, Zong-Hua;Wang, Jing;Yang, Yi-Hua;Dong, Wei;Shu, Yong-Xin;Zhao, Hai-Jun;Liao, Chun-Fang;Doilom, Mingkwan;Wang, Chao-Qun;Xia, Wen-Xiao;Li, Guo-Jie;Suwannarach, Nakarin;Senwanna, Chanokned;Suwannarach, Nakarin;Senwanna, Chanokned;Gafforov, Yusufjon;Gafforov, Yusufjon;Flakus, Adam;Suchan, Tomasz;Rodriguez-Flakus, Pamela;Plata, Oscar;Tamang, Juna;Acharya, Krishnendu;Tiendrebeogo, Assiata;Somda, Irenee;Decock, Cony;Tiendrebeogo, Assiata;Legreve, Anne;Yang, Yu;Xiao, Yuan-Pin;Zhou, Xian-Zhi;Li, Jia-Xin;Zhao, Rui-Lin;Wang, Shi-Hui;He, Mao-Qiang

    关键词：Ascomycota; Basidiomycota; New combination; New genus; New name; New record; New species

微信小程序