Pathogenic characteristics of Marek's disease virus field strains prevalent in China and the effectiveness of existing vaccines against them

文献类型： 外文期刊

第一作者： Zhang, Yan-ping

作者： Zhang, Yan-ping;Wang, Xiao-mei;Zhang, Yan-ping;Li, Zhi-jie;Bao, Ke-yan;Lv, Hong-chao;Gao, Yu-long;Gao, Hong-lei;Qi, Xiao-le;Cui, Hong-yu;Wang, Yong-qiang;Ren, Xian-gang;Wang, Xiao-mei;Liu, Chang-jun

作者机构：

关键词： Marek's disease virus;Pathogenicity;Prevalent;China

期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：3.293； 五年影响因子：3.599 ）

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收录情况： SCI

摘要： The virulence of Marek's disease virus (MDV) is continuously evolving, and more virulent MDV pathotypes are emerging, thereby reducing the effectiveness of the existing vaccines. In this study, feather pulps were collected from diseased chickens in commercial chicken flocks in China that presented significant MD visceral tumors in 2011 and were inoculated into a monolayer of duck embryo fibroblasts (DEFs). Three field isolates of MDV were obtained by plaque cloning and identified as MDV via PCR and designated strains LCC, LLY, and LTS. Unvaccinated and CVI988 vaccine-vaccinated specific pathogen-free chickens were challenged at 7 days post vaccination (dpv) with 1000 plaque forming units of each of the respective MDV isolates. These strains induced gross MD lesions in all (100%) of the unvaccinated chickens, and the mortality rates of the unvaccinated chickens were 42.9%, 46.7%, and 23.1% by 60 days post challenge (dpc), respectively. The CVI988 vaccine induced protective indices (PIs) of 85.7, 92.3, and 66.7, respectively. These results showed that the pathogenic characteristics of the Chinese isolates were diverse and that vaccine CVI988 provided different levels of protection against them. These data indicated that the existence of variant MDV strains was a possible reason of immunity failure in China. (C) 2015 Elsevier B.V. All rights reserved.

分类号： S8

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