Based on SERS conformational studies of ginsenoside Rb1 and its metabolites before and after combined with human serum albumin

文献类型： 外文期刊

第一作者： Zhang, Wei

作者： Zhang, Wei;Wang, Yingping;Bai, Xueyuan;Zhao, Bing

作者机构：

关键词： Ginsenoside Rb1/Rd/Rg3/CK;Human serum albumin;Surface-enhanced Raman scattering

期刊名称：SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY （ 影响因子：4.098； 五年影响因子：3.464 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Surface-enhanced. Raman scattering (SERS) and fluorescence spectroscopy were employed to probe the interaction of the pharmaceutical and natural product molecules, ginsenoside Rb1, Rd, Rg3 and compound K (CK), with human serum albumin (HSA). Normal Raman spectra of these four ginsenosides were obtained from solid powder on glass slide. Based on the unsplit peak at 1445 cm(-1), the stacking modes of ginsenoside Rb1, Rd, Rg3 and CK were quite similar, when the deconvolution of alkyl chain was not occurred. SERS spectra of ginsenoside Rb1, Rd, Rg3 and CK were obtained from a colloidal silver surface on a self-assembled SERS substrate, the most enhanced modes were those with certain motions perpendicular to the metal surface, such as C24=C25 stretch and C-H out-of-plane bending from alkyl chain. The SERS spectra were used to predict similar perpendicular orientation of flexible alkyl chain and parallel orientation of carbocyclic rings on Ag colloid particles. Therefore, when combined with HSA, the transformations of four ginsenosides still exhibit similar, although in different binding cavities in subdomain IIA and IIIA by making the methyls at C26 and C27 perpendicular plugging into the hydrophobic site of HSA, while the aglycone and glucose nearby are perpendicularly exposed outside to fit other suitable active targeting sites. (c) 2014 Elsevier B.V. All rights reserved.

分类号： O657.3

  • 相关文献

[1]Investigation of the binding sites and orientation of caffeine on human serum albumin by surface-enhanced Raman scattering and molecular docking. Wang, Weinan,Duan, Yaokai,Jiang, Yong,Zhang, Liangren,Tu, Pengfei,Zhang, Wei,Zhao, Bing.

[2]SERS study of different configurations of pharmaceutical and natural product molecules ginsenoside Rg3 under the interaction with human serum albumin on simple self-assembled substrate. Zhang, Wei,Wang, Yingping,Hou, Wei,Jin, Yinping,Bai, Xueyuan,Zhao, Yu,Zhao, Daqing,Zhao, Bing.

[3]Self-assembled nanosensor based on squaraine dye for specific recognition and detection of human serum albumin. Guo, Yanyan,Chen, Yiping,Zhu, Xiaochan,Fu, Nanyan,Guo, Yanyan,Chen, Yiping,Zhu, Xiaochan,Fu, Nanyan,Guo, Yanyan,Chen, Yiping,Zhu, Xiaochan,Fu, Nanyan,Pan, Zhizhen,Zhang, Xiangyu,Wang, Jian. 2018

[4]SERS spectroscopy of kaempferol and galangin under the interaction of human serum albumin with adsorbed silver nanoparticles. Zhang, Wei,Bai, Xueyuan,Zhao, Daqing,Zhao, Yu,Zhang, Wei,Wang, Yingping,Zhao, Bing.

[5]Molecular Structure-Affinity Relationship of Flavonoids in Lotus Leaf (Nelumbo nucifera Gaertn.) on Binding to Human Serum Albumin and Bovine Serum Albumin by Spectroscopic Method. Tang, Xiaosheng,Tang, Xiaosheng,Tang, Xiaosheng,Tang, Ping,Liu, Liangliang,Tang, Ping.

[6]Effects of gamma-Irradiation on the Molecular Structures and Functions of Human Serum Albumin. Hu, Xinxin,Song, Wei,Guo, Changying,Yu, Zehua,Liu, Rutao,Li, Wei,Guo, Changying.

作者其他论文 更多>>

微信小程序