Nanoemulsion-based delivery systems for nutraceuticals: Influence of carrier oil type on bioavailability of pterostilbene

文献类型: 外文期刊

第一作者: Sun, Yue

作者: Sun, Yue;Xia, Ziyuan;Zheng, Jinkai;Qiu, Peiju;McClements, David Julian;Xiao, Hang;Sun, Yue;Qiu, Peiju;Zhang, Lijuan;Zheng, Jinkai;McClements, David Julian

作者机构:

关键词: Nanoemulsion;Pterostilbene;Bioavailability;Metabolism;Olive oil;Flaxseed oil

期刊名称:JOURNAL OF FUNCTIONAL FOODS ( 影响因子:4.451; 五年影响因子:4.907 )

ISSN:

年卷期:

页码:

收录情况: SCI

摘要: Nanoemulsion-based delivery systems can be utilized in functional foods and beverages to improve the bioavailability of nutraceuticals. We determined the influence of carrier oil type on the bioavailability of pterostilbene encapsulated in nanoemulsions containing either flaxseed or olive oil as the carrier oil. The nanoemulsions were then subjected to a simulated gastrointestinal tract (mouth, stomach, small intestine), and the resulting micelle phases were used to establish pterostilbene bioavailability using a Caco-2 cell model. Both nanoemulsions significantly enhanced the bioaccessibility of pterostilbene within the micelle phase. However, olive oil nanoemulsions increased trans-enterocyte transport of pterostilbene more effectively than flaxseed oil ones. Moreover, the patterns of metabolism of pterostilbene during its trans-enterocyte transport were dramatically different when pterostilbene was delivered using nanoemulsions with different carrier oil types. (C) 2014 Elsevier Ltd. All rights reserved.

分类号: TS2

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