CCAAT-enhancer binding protein (C/EBP) beta regulates insulin-like growth factor (IGF) 1 expression in porcine liver during prenatal and postnatal development

文献类型： 外文期刊

第一作者： Tang, Yiting

作者： Tang, Yiting;Xiong, Kai;Shen, Ming;Liu, Honglin;Tang, Yiting;Mu, Yulian;Li, Kui;Xiong, Kai

作者机构：

关键词： C/EBP beta;IGF1;Liver;Transcription factor;Porcine

期刊名称：MOLECULAR AND CELLULAR BIOCHEMISTRY （ 影响因子：3.396； 五年影响因子：3.282 ）

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年卷期：

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收录情况： SCI

摘要： IGF1 expression regulation attracts numerous interests because of its important role during mammalian growth and development. Domestic pig can be used as a valuable animal model to investigate human development since they share the high similarity in general physiology and metabolism. In this study, we examined the expression pattern of IGF1 and found it associated with liver C/EBP beta expression pattern in porcine liver during embryonic and postnatal development. Both IGF1 and C/EBP beta expression in liver maintained at low levels before birth and increased after birth. Correspondingly, C/EBP beta demonstrated high binding activity to two sites at IGF1 promoter region in liver after birth. Additionally, IGF1 expression can be activated by C/EBP beta overexpression in porcine primary hepatocytes. These results indicated that C/EBP beta can activate IGF1 expression after birth by binding to IGF1 promoter. Our study may contribute to a better understanding of mammalian development and bring a novel anti-aging pathway in human.

分类号： Q5

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