CCAAT-enhancer binding protein (C/EBP) beta regulates insulin-like growth factor (IGF) 1 expression in porcine liver during prenatal and postnatal development

文献类型： 外文期刊

第一作者： Tang, Yiting

作者： Tang, Yiting;Xiong, Kai;Shen, Ming;Liu, Honglin;Tang, Yiting;Mu, Yulian;Li, Kui;Xiong, Kai

作者机构：

关键词： C/EBP beta;IGF1;Liver;Transcription factor;Porcine

期刊名称：MOLECULAR AND CELLULAR BIOCHEMISTRY （ 影响因子：3.396； 五年影响因子：3.282 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： IGF1 expression regulation attracts numerous interests because of its important role during mammalian growth and development. Domestic pig can be used as a valuable animal model to investigate human development since they share the high similarity in general physiology and metabolism. In this study, we examined the expression pattern of IGF1 and found it associated with liver C/EBP beta expression pattern in porcine liver during embryonic and postnatal development. Both IGF1 and C/EBP beta expression in liver maintained at low levels before birth and increased after birth. Correspondingly, C/EBP beta demonstrated high binding activity to two sites at IGF1 promoter region in liver after birth. Additionally, IGF1 expression can be activated by C/EBP beta overexpression in porcine primary hepatocytes. These results indicated that C/EBP beta can activate IGF1 expression after birth by binding to IGF1 promoter. Our study may contribute to a better understanding of mammalian development and bring a novel anti-aging pathway in human.

分类号： Q5

  • 相关文献

[1]IGF1 regulates RUNX1 expression via IRS1/2: Implications for antler chondrocyte differentiation. Yang, Zhan-Qing,Zhang, Hong-Liang,Geng, Shuang,Wang, Kai,Yu, Hai-Fan,Yue, Zhan-Peng,Guo, Bin,Duan, Cui-Cui. 2017

[2]Duplicated CCAAT/enhancer-binding protein beta (C/EBP beta) gene: Transcription and methylation changes in response to dietary betaine in Landes goose liver. Yu, S. L.,Li, Q. F.,Xie, Z.,Su, S. Y.,Zhang, X.. 2013

[3]Transcriptional regulation analysis of FAM3A gene and its effect on adipocyte differentiation. Kang, Tingting,Peng, Disha,Bu, Guowei,Gu, Hao,Zhang, Feng,Zhang, Ruirui,Zhou, Ying,Xiong, Yuanzhu,Lei, Minggang,Kang, Tingting,Peng, Disha,Bu, Guowei,Gu, Hao,Zhang, Ruirui,Zhou, Ying,Xiong, Yuanzhu,Lei, Minggang,Zhang, Feng.

[4]Transcription factor C/EBP beta and 17 beta-estradiol promote transcription of the porcine p53 gene. Tao, Hu,Zhang, Xuying,Yang, Jiahao,Zhu, Lihua,Zhou, Jiawei,Wang, Lei,Hua, Lun,Li, Fenge,Tao, Hu,Zhang, Xuying,Yang, Jiahao,Zhu, Lihua,Zhou, Jiawei,Wang, Lei,Hua, Lun,Li, Fenge,Mei, Shuqi,Peng, Xianwen,Wu, Huayu.

[5]Protein-DNA interactions in the promoter region of the gene encoding diapause hormone and pheromone biosynthesis activating neuropeptide of the cotton bollworm, Helicoverpa armigera. Hong, B,Zhang, ZF,Tang, SM,Yi, YZ,Zhang, TY,Xu, WH.

[6]Molecular cloning, tissue expression pattern, and copy number variation of porcine SCUBE3. Liu, X.,Wang, L. G.,Zhang, L. C.,Yan, H.,Zhao, K. B.,Liang, J.,Li, N.,Pu, L.,Zhang, T.,Wang, L. X.. 2016

[7]Expression Profiling of miRNA-122 and miRNA-221 in Porcine Various Tissues and Developing Testes. Lian, Chuanjiang,Niu, Shuling,Yang, Runjun,Sun, Boxing,Shen, Binglei,Liu, Boyang,Zhang, Liying,Zhao, Zhihui,Qin, Lihong,Bai, Wenlin. 2011

[8]Promoter Characterization and Expression Pattern Analysis of Porcine TCAP Gene. Qiao, Mu,Wu, Huayu,Huang, Jingshu,Peng, Xianwen,Liu, Guisheng,Feng, Zheng,Mei, Shuqi. 2012

[9]Identification and functional analysis of a novel single nucleotide polymorphism (SNP) in the porcine Toll like receptor (TLR) 5 gene. Li, H. -T.,Yang, X. -Q.,Liu, D.. 2011

[10]MicroRNA-34c regulates porcine granulosa cell function by targeting forkhead box O3a. Xu Yuan,Zhang Zhe,Yuan Xiao-long,Chen Zan-mou,Zhang Hao,Li Jia-qi,Zhang Ai-ling. 2017

[11]Molecular cloning and expression pattern of the porcine 5-aminolevulinate synthase 1 (ALAS1) gene and its association with reproductive traits. Liu, L. Q.,Li, F. E.,Deng, C. Y.,Li, F. E.,Deng, C. Y.. 2016

[12]Systemic analysis of gene expression profiles in porcine granulosa cells during aging. Li Hui,Guo Shuangshuang,Yu Jianning,Shi Zhendan. 2017

[13]Prevalence of hepatitis E virus and porcine caliciviruses in pig farms of Guizhou province, China. Hua, Xiuguo,Shen, Quan,Shen, Quan,Zhang, Wen,Ren, Rongqing. 2011

[14]Establishment of real-time TaqMan-fluorescence quantitative RT-PCR assay for detection and quantitation of ten kinds of porcine inflammation markers mRNA. Lin, Wencheng,Qiu, Zheng,Liu, Qinfang,Cui, Shangjin,Wang, Zhongtian.

[15]Influence of acrylamide on ROS, Hsp27 and NF-kappa B in bone marrow mesenchymal stem cells. Liu, Yang,Tao, Xiaoli,Mu, Yulian,Wang, Pan,Feng, Shutang,Li, Kui,Liu, Yang,Mu, Yulian,Wang, Pan,Feng, Shutang,Li, Kui,Liu, Yang,Mu, Yulian,Wang, Pan,Feng, Shutang,Li, Kui,Tao, Xiaoli.

[16]TALEN construction for porcine I kappa B alpha gene and the detection of knockout activity. Xu, Kui,Ruan, Jinxue,Li, Hegang,Wu, Tianwen,Liang, Bo,Mu, Yulian,Li, Hegang.

[17]Partial molecular characterization, expression pattern, polymorphism and association analysis of porcine SKP2 gene. Li, Y.,Zhao, S. H.,Peng, K. M.,Li, Y.,Yang, S. L.,Tang, Z. L.,Cui, W. T.,Mu, Y. L.,Chu, M. X.,Li, K.,Li, Y.,Wu, Z. F..

[18]Dynamic Expression of MicroRNA-127 During Porcine Prenatal and Postnatal Skeletal Muscle Development. Yang Ya-lan,Li Yan,Liang Ru-yi,Zhou Rong,Ao Hong,Mu Yu-lian,Yang Shu-lin,Li Kui,Tang Zhong-lin,Li Yan. 2014

[19]Isolating, Mapping and Spatio-Temporal Distribution Analysis of Five Ubiquitin-Specific Protease Genes in Porcine. Wu, X.,Zhu, L. L.,Tan, Y. S.,Tang, X. M.,Wu, X.,Zhu, L. L.,Tang, X. M.,Zhang, X. B.. 2011

[20]Porcine MAP3K5 analysis: molecular cloning, characterization, tissue expression pattern, and copy number variations associated with residual feed intake. Pu, L.,Zhang, L. C.,Zhang, J. S.,Wang, L. G.,Liang, J.,Zhang, Y. B.,Liu, X.,Yan, H.,Zhang, T.,Yue, J. W.,Wang, L. X.,Song, X.,Li, N.,Wu, Q. Q.. 2016

作者其他论文 更多>>
  • EXPERT expands prime editing efficiency and range of large fragment edits

    作者：Xiong, Youcai;Su, Yinyu;He, Ruigao;Han, Xiaosong;Li, Sheng;Liu, Minghuan;Xi, Xiaoning;Liu, Zijia;Wang, Heng;Xie, Shengsong;Xu, Xuewen;Li, Xinyun;Zhao, Shuhong;Ruan, Jinxue;Xiong, Youcai;Su, Yinyu;He, Ruigao;Han, Xiaosong;Li, Sheng;Liu, Minghuan;Xi, Xiaoning;Liu, Zijia;Wang, Heng;Xie, Shengsong;Xu, Xuewen;Li, Xinyun;Zhao, Shuhong;Ruan, Jinxue;Han, Xiaosong;Zhao, Shuhong;Xie, Shengsong;Xu, Xuewen;Li, Xinyun;Zhao, Shuhong;Xie, Shengsong;Xu, Xuewen;Li, Xinyun;Zhao, Shuhong;Li, Kui;Zhang, Jifeng;Xu, Jie

    关键词：

  • Genome-Wide Silencer Screening Reveals Key Silencer Modulating Reprogramming Efficiency in Mouse Induced Pluripotent Stem Cells

    作者：Zhu, Xiusheng;Huang, Lei;Li, Guoli;Deng, Biao;Wang, Xiaoxiao;Yang, Hu;Zhang, Yuanyuan;Wen, Qiuhan;Wang, Chao;Zhang, Jingshu;Li, Kui;Liu, Yuwen;Deng, Biao;Deng, Biao;Zhao, Yunxiang

    关键词：cis-regulatory elements; high-throughput; iPSCs; silencer; Ss-STARR-seq

  • Transcriptome analysis reveals no obvious unintended effects in the spleen of CRISPR/Cas9-mediated CD163 and pAPN double-knockout pigs

    作者：Liu, Zhi-Guo;Wang, Nan;Wang, Wan-Jie;Chi, Shun-Shun;Nie, Yu-Xin;Yuan, Mao-Sha;Sun, Ya-Ru;Mu, Yu-Lian;Li, Kui;Wang, Nan;Huang, Lei;Chi, Shun-Shun;Li, Kui

    关键词：CD163; pAPN; Double-knockout; Gene editing; Pig; Spleen; Unintended effects; Transcriptomics

  • Integrating large-scale meta-GWAS and PigGTEx resources to decipher the genetic basis of 232 complex traits in pigs

    作者：Xu, Zhiting;Lin, Qing;Cai, Xiaodian;Zhong, Zhanming;Teng, Jinyan;Zeng, Haonan;Gao, Yahui;Wei, Chen;Zhou, Jun;Zhang, Wenjing;Zhang, Xiaoke;Shi, Shaolei;Wu, Jun;Diao, Shuqi;Liu, Yuqiang;Pan, Xiangchun;Feng, Xueyan;Liu, Ruiqi;Su, Zhanqin;Chang, Chengjie;Zhu, Qianghui;Wu, Yuwei;Zhang, Hao;Yuan, Xiaolong;Li, Jiaqi;Zhang, Zhe;Li, Bingjie;Gao, Yahui;Liu, George E.;Gao, Yahui;Ma, Li;Cai, Zexi;Bai, Zhonghao;Su, Guosheng;Sahana, Goutam;Lund, Mogens Sando;Fang, Lingzhao;Wang, Xiaoqing;Shi, Liangyu;Zhao, Fuping;Wang, Xue;Wang, Yi;Zhang, Zipeng;Ding, Xiangdong;Lin, Yu;Tang, Guoqing;Li, Mingzhou;Li, Xuewei;Liu, Shuli;Yin, Hongwei;Bai, Lijing;Li, Kui;Zhou, Zhongyin;Wang, Qishan;Pan, Yuchun;Xu, Zhong;Peng, Xianwen;Mei, Shuqi;Mo, Delin;Liu, Xiaohong;Chen, Yaosheng;Liu, Yang;Xiang, Ruidong;Xiang, Ruidong;Shen, Xia;Shen, Xia;Shen, Xia;Li, Pinghua;Huang, Ruihua;Li, Pinghua;Huang, Ruihua;Ballester, Maria;Crespo-Piazuelo, Daniel;Amills, Marcel;Clop, Alex;Amills, Marcel;Karlskov-Mortensen, Peter;Fredholm, Merete;Zhang, Qin;Zhao, Yunxiang

    关键词：pig; meta-GWAS; PigGTEx; molQTL; complex traits

  • Life table study of sublethal concentrations of emamectin benzoate against Spodoptera frugiperda (Lepidoptera, Noctuidae)

    作者：Chen, Chengyu;Tang, Yiting;Zhao, Yunxia;Zhang, Xuefeng;Zhang, Kai;Chen, Chengyu;Tang, Yiting;Zhao, Yunxia;Zhang, Xuefeng;Zhang, Kai

    关键词：emamectin benzoate; Spodoptera frugiperda; sublethal effects; population growth parameters; two-sex life table

  • Multi-dimensional annotation of porcine variants using genomic and epigenomic features in pigs

    作者：Yin, Hongwei;Yang, Liu;Zhao, Qianyi;Yao, Wenye;Bai, Lijing;Li, Kui;Fang, Lingzhao;Yao, Wenye;Groenen, Martien A. M.;Madsen, Ole;Teng, Jinyan;Gao, Yahui;Xu, Zhiting;Lin, Qing;Diao, Shuqi;Li, Jiaqi;Zhang, Zhe;Zhou, Huaijun;Guan, Dailu;Liu, Xiaohong;Zhao, Fuping;Zhou, Zhongyin;Wang, Qishan

    关键词：Genomic variants; Gene expression and splicing; Complex traits; Non-coding regions; Epigenome

  • DPImpute: A Genotype Imputation Framework for Ultra-Low Coverage Whole-Genome Sequencing and its Application in Genomic Selection

    作者：Zheng, Weigang;Wang, Chao;Dong, Wenjun;Liu, Yuwen;Zheng, Weigang;Wang, Chao;Dong, Wenjun;Liu, Yuwen;Zheng, Weigang;Ma, Wenlong;Chen, Zhilong;Wang, Chao;Sun, Tao;Dong, Wenjun;Zhang, Song;Tang, Zhonglin;Li, Kui;Liu, Yuwen;Zheng, Weigang;Ma, Wenlong;Chen, Zhilong;Wang, Chao;Sun, Tao;Dong, Wenjun;Zhang, Song;Tang, Zhonglin;Li, Kui;Liu, Yuwen;Zhang, Wenjing;Tang, Zhonglin;Liu, Yuwen;Zhao, Yunxiang

    关键词：breeding models; genetic screening of embryos; genomic selection; genotype imputation; single cell genotype

微信小程序