Similar regulation of two distinct UL24 promoters by regulatory proteins of equine herpesvirus type 1 (EHV-1)

文献类型: 外文期刊

第一作者: Ma, Yue

作者: Ma, Yue;Liu, Diqiu;Wang, Xiaojun;Gao, Jun;Wang, Xiaojun

作者机构:

关键词: Equine herpesvirus type 1;UL24;Double promoters;Transcriptional regulation;Regulatory protein

期刊名称:FEBS LETTERS ( 影响因子:4.124; 五年影响因子:3.814 )

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收录情况: SCI

摘要: To characterise the pattern of the transcriptional regulation of equine herpesvirus type 1 (EHV-1) UL24 by regulatory proteins, we identified two distinct promoter regions and two transcription initiation (Tci) sites located upstream of the UL24 open reading frame (ORF). The ORF proximal promoter exhibited higher cis-activity than that of the distal one. Contrary to the former, the latter performed its function dependent on an initiator (INR) due to its lack of a TATA box. Our results showed that the EHV-1 regulatory proteins EICP0, EICP22 and ETIF trans-activated the two promoters, whereas IEP and IR2P displayed negative regulation. In summary, the regulatory proteins exhibited similar regulatory patterns for the two distinct promoters of EHV-1 UL24. (C) 2015 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.

分类号: Q5

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