Chemical characteristics and antithrombotic effect of chondroitin sulfates from sturgeon skull and sturgeon backbone

文献类型： 外文期刊

第一作者： Gui, Meng

作者： Gui, Meng;Song, Juyi;Zhang, Lu;Wu, Ruiyun;Ma, Changwei;Li, Pinglan;Song, Juyi;Wang, Shun

作者机构：

关键词： Sturgeon;Chondroitin sulfate;Anticoagulant;Anti-platelet aggregation;Thrombolysis

期刊名称：CARBOHYDRATE POLYMERS （ 影响因子：9.381； 五年影响因子：8.678 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Chondroitin sulfates (CSs) were extracted from sturgeon skull and backbone, and their chemical composition, anticoagulant, anti-platelet and thrombolysis activities were evaluated. The average molecular weights of CS from sturgeon skull and backbone were 38.5 kDa and 49.2 kDa, respectively. Disaccharide analysis indicated that the sturgeon backbone CS was primarily composed of disaccharide monosulfated in position four of the GalNAc (37.8%) and disaccharide monosulfated in position six of the GalNAc (59.6%) while sturgeon skull CS was primarily composed of nonsulfated disaccharide (74.2%). Sturgeon backbone CS showed stronger antithrombotic effect than sturgeon skull CS. Sturgeon backbone CS could significantly prolong activated partial thromboplastin time (APTT) and thrombin time (TT), inhibited ADP-induced platelet aggregation and dissolved platelet plasma clots in vitro. The results suggested that sturgeon backbone CS can be explored as a functional food with antithrombotic function. (C) 2015 Elsevier Ltd. All rights reserved.

分类号： O629`Q53

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