Simultaneous determination of 38 veterinary antibiotic residues in raw milk by UPLC-MS/MS

文献类型： 外文期刊

第一作者： Zheng, N.

作者： Zheng, N.;Xu, X. M.;Qu, X. Y.;Li, S. L.;Zhang, Y. D.;Wang, J. Q.;Han, R. W.;Yu, Z. N.;Wang, J.;Zheng, N.;Xu, X. M.;Qu, X. Y.;Li, S. L.;Zhang, Y. D.;Wang, J. Q.;Zheng, N.;Xu, X. M.;Qu, X. Y.;Li, S. L.;Zhang, Y. D.;Wang, J. Q.

作者机构：

关键词： Veterinary antibiotics;Multiclass analysis;Raw milk;UPLC MS/MS

期刊名称：FOOD CHEMISTRY （ 影响因子：7.514； 五年影响因子：7.516 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： A selective and rapid method has been developed to determine, simultaneously, 38 veterinary antibiotic residues in raw milk by ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). One milliliter of raw milk was diluted with 0.5 mL water and 3 mL acetonitrile, then purified using an Oasis HLB cartridge. The eluates were evaporated by nitrogen drying and then reconstituted to 4 mL with water/acetonitrile (8:1) before being injected into the UPLC-MS/MS system. The results indicated recoveries of 68-118% for 14 beta-lactams, 79-118% for eight quinolones, 71-106% for eight sulfonamides, 76-116% for four tetracyclines, 78-106% for three macrolides, and 88-103% for one lincosamides, with coefficients of variation less than 15% for intraday and interday precisions. The limit of quantification for all antibiotics was 0.03-10 mu g kg(-1). This methodology was then applied to field-collected real raw milk samples and trace levels of four antibiotics were detected. (C) 2015 Elsevier Ltd. All rights reserved.

分类号： TS2`TS201.2

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