Effects of dietary hull-less barley beta-glucan on the cholesterol metabolism of hypercholesterolemic hamsters

文献类型： 外文期刊

第一作者： Tong, Li-Tao

作者： Tong, Li-Tao;Zhong, Kui;Liu, Liya;Zhou, Xianrong;Zhou, Sumei;Qiu, Ju

作者机构：

关键词： Hull-less barley beta-glucan;Oat beta-glucan;Hypercholesterolemia;Fecal lipids;Short-chain fatty acids;Hamsters

期刊名称：FOOD CHEMISTRY （ 影响因子：7.514； 五年影响因子：7.516 ）

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收录情况： SCI

摘要： The aim of the present study is to investigate the hypocholesterolemic effects of dietary hull-less barley beta-glucan (HBG) on cholesterol metabolism in hamsters which were fed a hypercholesterolemic diet. The hamsters were divided into 3 groups and fed experimental diets, containing 5 parts per thousand HBG or 5 parts per thousand oat beta-glucan (OG), for 30 days. The HBG, as well as OG, lowered the concentration of plasma LDL-cholesterol significantly. The excretion of total lipids and cholesterol in feces were increased in HBG and OG groups compared with the control group. The activity of 3-hydroxy-3-methyl glutaryl-coenzyme A (HMG-CoA) reductase in liver was reduced significantly in the HBG group compared with the control and OG groups. The activity of cholesterol 7-alpha hydroxylase (CYP7A1) in the liver, in the HBG and OG groups, was significantly increased compared with the control group. The concentrations of acetate, propionate and total short chain fatty acids (SCFAs) were not significantly different between the HBG and control groups. These results indicate that dietary HBG reduces the concentration of plasma LDL cholesterol by promoting the excretion of fecal lipids, and regulating the activities of HMG-CoA reductase and CYP7A1 in hypercholesterolemic hamsters. (C) 2014 Elsevier Ltd. All rights reserved.

分类号： TS2`TS201.2

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