Inhibition effects of Chinese cabbage powder on aflatoxin B1-induced liver cancer

文献类型： 外文期刊

第一作者： Wang, Tuoyi

作者： Wang, Tuoyi;Li, Chunyan;Liu, Yang;Li, Tiezhu;Zhang, Jie;Zhang, Jie;Sun, Yonghai

作者机构：

关键词： Chinese cabbage powder;Vegetable food;Aflatoxin B-1;Antitumor activities;Liver tumor

期刊名称：FOOD CHEMISTRY （ 影响因子：7.514； 五年影响因子：7.516 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： In this study, 0.25 mu g/ml aflatoxin B-1 was used to establish a liver cancer model for assessing the potential anticancer ability of Chinese cabbage powder, which is a complex water-soluble extract from Chinese cabbage by spray-drying at an outlet temperature of 130 degrees C. We found at least 11 potential anticancer substances in Chinese cabbage powder. A 90-d animal experiment demonstrated that 10% of Chinese cabbage powder in drinking water could improve the plasma micronutrient status, inhibit the formation of aflatoxin B1-DNA adducts in liver cells, and effectively reduce the incidence of liver tumor induced by aflatoxin B-1 from 6.67% to 0%. The dose effect experiment revealed that 10% may be the minimal effective dose to prevent the occurrence of early liver tumors. This study will help elucidate the basis of epidemiological observations of dietary cancer prevention in humans, as well as explore related mechanisms. (C) 2015 Elsevier Ltd. All rights reserved.

分类号： TS2`TS201.2

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