文献类型: 外文期刊
第一作者: Lu, Zhen
作者: Lu, Zhen;Zhang, Lizhou;Wang, Nian;Chen, Yuming;Gao, Li;Wang, Yongqiang;Gao, Honglei;Gao, Yulong;Li, Kai;Qi, Xiaole;Wang, Xiaomei;Wang, Xiaomei
作者机构:
关键词: Infectious bursal disease virus (IBDV);Reassortant;Genome;Evolution
期刊名称:VIRUS RESEARCH ( 影响因子:3.303; 五年影响因子:3.445 )
ISSN:
年卷期:
页码:
收录情况: SCI
摘要: Infectious bursal disease virus (IBDV) is a bi-segmented, double-stranded RNA virus that belongs to the genus Avibirnavirus of the family of Bimavirideae. The co-evolution of genome segments is a major evolutionary feature for IBDV. However, in recent years, some strains exhibited markedly different genetic relationships for segments A and B. In this study, we firstly isolated a new type of reassortment IBDV strain named IBD13HeB01 from northern China. The full-length genomes of segments A and B were cloned and identified. Sequence analysis revealed that IBD13HeB01 was a segment-reassortment strain, whose segment A was derived from very virulent strain and segment B from attenuated IBDV. In addition, the virulence of IBD13HeB01 strain was evaluated using SPF chickens. This study is not only beneficial for further understanding of the viral evolution but also suggests the potential risk of application of the live vaccines of IBDV. (C) 2015 Elsevier B.V. All rights reserved.
分类号: R37
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