The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development

文献类型： 外文期刊

第一作者： Yu, Yong

作者： Yu, Yong;Wang, Cui;Clare, Simon;Wang, Juexuan;Lee, Song-Choon;Brandt, Cordelia;Burke, Shannon;Lu, Liming;Dougan, Gordon;Liu, Pentao;Wang, Cui;He, Daqian;Jenkins, Nancy A.;Copeland, Neal G.;Lu, Liming

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期刊名称：JOURNAL OF EXPERIMENTAL MEDICINE （ 影响因子：14.307； 五年影响因子：14.851 ）

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收录情况： SCI

摘要： Group 2 innate lymphoid cells (ILCs), or ILC2s, are a subset of recently identified ILCs, which play important roles in innate immunity by producing type 2 effector cytokines. Several transcription factors have been found to have critical functions in the development of both ILC2s and T cells. We report here that Bcl11b, a transcription factor essential in T cell lineage commitment and maintenance, is specifically expressed in progenitors committed to the ILC2 lineage and is required for ILC2 development. The Bcl11b gene is expressed in similar to 28% of ILC progenitors (ILCPs; common helper innate lymphoid progenitors or ILCPs expressing either ID2 or promyelocytic leukemia zinc finger, respectively). Both in vitro and in vivo, these Bcl11b-expressing early ILCPs generate only ILC2s. Inactivation of Bcl11b causes a complete loss of ILC2 development from hematopoietic progenitors, which is confirmed upon immune challenge with either papain administration or influenza virus infection.

分类号： R

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