Duck tembusu virus and its envelope protein induce programmed cell death

文献类型： 外文期刊

第一作者： Shaozhou, Wulin

作者： Shaozhou, Wulin;Li, Chenxi;Zhang, Qingshan;Meng, Runzhe;Gao, Youlan;Liu, Hongyu;Bai, Xiaofei;Chen, Yuhuan;Liu, Ming;Liu, Siguo;Zhang, Yun

作者机构：

关键词： Flaviviruses;Duck tembusu virus;Envelope glycoprotein E;Apoptosis;DEVDase activity

期刊名称：VIRUS GENES （ 影响因子：2.332； 五年影响因子：2.0 ）

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年卷期：

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收录情况： SCI

摘要： The cytopathic effect produced in cells infected with duck tembusu virus (DTMUV) suggests that this emerging virus may induce apoptosis in primary cultures of duck embryo fibroblasts (DEF). Here, we present evidence that DTMUV infection of cultured cells activates apoptosis and that the ability of DTMUV to induce apoptosis is not restricted to cell type because DTMUV-induced apoptosis in duck and mammalian host cells. We further investigated which viral components induce apoptosis in DTMUV-in-fected host cells. The major envelope glycoprotein (E) was investigated for its apoptotic activities in expressed cells. Transient expression of the E protein alone triggered apoptosis in DEF, Vero, and BHK cells. Expression of the E protein resulted in activation of caspase-3-like proteases in cultured cells. These results indicate that infection of cells with DTMUV or expression of DTMUV E protein alone induces apoptosis, providing the basis for future to define the molecules that play key roles in the fate of DTMUV-infected cells.

分类号： R37

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