Selective actions of Lynx proteins on different nicotinic acetylcholine receptors in the locust, Locusta migratoria manilensis

文献类型： 外文期刊

第一作者： Wang, Xin

作者： Wang, Xin;Bao, Haibo;Sun, Huahua;Zhang, Yixi;Liu, Qinghong;Liu, Zewen;Bao, Haibo;Fang, Jichao

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关键词： Locusta migratoria manilensis;Lynx;nicotinic acetylcholine receptors;selectivity

期刊名称：JOURNAL OF NEUROCHEMISTRY （ 影响因子：5.372； 五年影响因子：5.69 ）

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收录情况： SCI

摘要： Nicotinic acetylcholine receptors (nAChRs) are major neurotransmitter receptors and targets of neonicotinoid insecticides in the insect nervous system. The full function of nAChRs is often dependent on associated proteins, such as chaperones, regulators and modulators. Here, three Lynx (Ly-6/neurotoxin) proteins, Loc-lynx1, Loc-lynx2 and Loc-lynx3, were identified in the locust, Locusta migratoria manilensis. Co-expression with Lynx resulted in a dramatic increase in agonist-evoked macroscopic currents on nAChRs Loc1/2 and Loc2/2 in Xenopus oocytes, but no changes in agonist sensitivity. Loc-lynx1 and Loc-lynx3 only modulated nAChRs Loc1/2 while Loc-lynx2 modulated Loc2/2 specifically. Meanwhile, Loc-lynx1 induced a more significant increase in currents evoked by imidacloprid and epibatidine than Loc-lynx3, and the effects of Loc-lynx1 on imidacloprid and epibatidine were significantly higher than those on acetylcholine. Among three lynx proteins, only Loc-lynx1 significantly increased [H-3]epibatidine binding on Loc1/2. The results indicated that Loc-lynx1 had different modulation patterns in nAChRs compared to Loc-lynx2 and Loc-lynx3. Taken together, these findings indicated that three Lynx proteins were nAChR modulators and had selective activities in different nAChRs. Lynx proteins might display their selectivities from three aspects: nAChR subtypes, various agonists and different modulation patterns.

分类号： Q5

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