Chlorpyrifos is estrogenic and alters embryonic hatching, cell proliferation and apoptosis in zebrafish

文献类型： 外文期刊

第一作者： Yu, Kaimin

作者： Yu, Kaimin;Li, Guochao;Feng, Weimin;Liu, Lili;Zhang, Jiayu;Wu, Wei;Xu, Lei;Yan, Yanchun

作者机构：

关键词： Chlorpyrifos;Embryonic hatching;Cell proliferation;Apoptosis;Zebrafish

期刊名称：CHEMICO-BIOLOGICAL INTERACTIONS （ 影响因子：5.192； 五年影响因子：4.61 ）

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收录情况： SCI

摘要： The potential interference of endocrine disrupting chemicals (EDCs) on aquatic animals and humans has drawn wide attention in recent years. Reports have shown that some organophosphorus pesticides were a kind of EDCs, but their effects on fish species are still under research. In present study, flow cytometry data of HEC-1B cell line showed that chlorpyrifos (CPF) could increase cell proliferation index like 17 beta-estradiol (E2), but the effect of CPF was weaker than of E2 in the same concentration. Moreover, CPF altered the expression pattern of estrogen-responsive gene VTG and ER alpha in zebrafish embryos. When exposed to CPF at various concentrations (0, 0.10, 0.25, 0.50, 0.75 and 1.00 mg/L) for 48 h during the embryo stage, compared with controls, the hatching rate of treated groups significantly increased at the same time and the hatching rate of embryos was proportional to CPF concentration. The mRNA expression levels of c-myc, cyclin D1, Bax and Bcl-2, which are closely related to cell proliferation and cell apoptosis, were disturbed by CPF in zebrafish embryos after exposure treated for 48 h. In addition, acridine orange (AO) staining of zebrafish embryos showed that cell apoptosis was appeared in the 0.75, 1.00 mg/L CPF treated groups. Taken together, the results obtained in the present study indicated that chlorpyrifos is estrogenic and alters embryonic hatching, cell proliferation and apoptosis in zebrafish. (C) 2015 Published by Elsevier Ireland Ltd.

分类号： Q5

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