A broad protection provided by matrix protein 2 (M2) of avian influenza virus

文献类型： 外文期刊

第一作者： Meng, Qingwen

作者： Meng, Qingwen;Liu, Guangliang;Liu, Yonggang;Wang, Wei;Chen, Hongyan;Deng, Xiaoxia;Xu, Kehui;Zheng, Xiangdong;Zhang, Dongwei;Pang, Hai;Liu, Guangliang

作者机构：

关键词： Influenza A virus;M2 protein;Antibody;Vaccine;Protection

期刊名称：VACCINE （ 影响因子：3.641； 五年影响因子：3.816 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： To prevent a future influenza A virus subtype pandemic outbreak, developing a broad-spectrum vaccine would be highly beneficial. The ion channel protein M2 is highly conserved in a diverse number of influenza A virus subtypes. This distinguishing characteristic makes M2 an attractive vaccine target for a broadly protective vaccine. We expressed a full-length M2 protein which was C-terminally fused to a small peptide in Escherichia coil. Because this recombinant M2 (rM2) protein forms multimeric complexes with high molecular weight, it serves as a potential immunogen. Antibodies induced by the rM2 protein prevented the replication of different subtypes of influenza A virus both in vitro and in vivo. Animal study demonstrated that rM2 immunization protected mice against influenza A virus infection via limiting replication of virus progeny in vivo and attenuating lung damage. As such, the M2 protein is a highly potential candidate for next generation vaccine development with the capability of protecting against various influenza A virus subtypes. (C) 2015 Elsevier Ltd. All rights reserved.

分类号： R392

  • 相关文献

[1]A multivalent killed whole-cell vaccine induces effective protection against Edwardsiella tarda and Vibrio anguillarum. Sun, Yun,Sun, Li,Liu, Chun-sheng,Sun, Yun.

[2]Effects of dietary vitamin E on immunological stress of layers and their offspring. Zhao, G. P.,Han, M. J.,Zheng, M. Q.,Zhao, J. P.,Chen, J. L.,Wen, J..

[3]A proviral derivative from a reference attenuated EIAV vaccine strain failed to elicit protective immunity. Ma, Jian,Shi, Nan,Jiang, Cheng-Gang,Lin, Yue-Zhi,Wang, Xue-Feng,Wang, Shuai,Lv, Xiao-Ling,Zhao, Li-Ping,Kong, Xian-Gang,Zhou, Jian-Hua,Shen, Rong-Xian,Ma, Jian,Shao, Yi-Ming. 2011

[4]Immunogenicity and protective efficacy of an inactivated cell culture-derived Seneca Valley virus vaccine in pigs. Yang, Fan,Zhu, Zixiang,Cao, Weijun,Liu, Huanan,Zhang, Keshan,Tian, Hong,Liu, Xiangtao,Zheng, Haixue. 2018

[5]Comparison of immune responses against foot-and-mouth disease virus induced by fusion proteins using the swine IgG heavy chain constant region or beta-galactosidase as a carrier of immunogenic epitopes. Li, GJ,Chen, WZ,Yan, WY,Zhao, K,Liu, MQ,Zhang, J,Fei, L,Xu, QX,Sheng, ZT,Lu, YG,Zheng, ZX.

[6]H5N1 influenza virus-like particle vaccine protects mice from heterologous virus challenge better than whole inactivated virus. Ren, Zhiguang,Qin, Chuan,Xia, Xianzhu,Ren, Zhiguang,Qin, Chuan,Xia, Xianzhu,Ren, Zhiguang,Ji, Xianliang,Meng, Lingnan,Wei, Yurong,Wang, Tiecheng,Feng, Na,Zheng, Xuexing,Wang, Hualei,Li, Nan,Gao, Xiaolong,Zhao, Yongkun,Yang, Songtao,Gao, Yuwei,Xia, Xianzhu,Ji, Xianliang,Meng, Lingnan,Wei, Yurong,Jin, Hongli,Gao, Yuwei,Xia, Xianzhu,Gao, Yuwei,Xia, Xianzhu.

[7]Comparative study of the immune effect of an Edwardsiella tarda antigen in two forms: Subunit vaccine vs DNA vaccine. Sun, Yun,Sun, Li,Sun, Yun,Liu, Chun-Sheng.

[8]Antibody Developments and Immunoassays for Organophosphorus Chemicals: A Review. Hua, Xiude,Liu, Fengquan,Wang, Minghua,Hua, Xiude,Liu, Fengquan,Wang, Minghua,Eremin, Sergei A.,Eremin, Sergei A.,Liu, Fengquan. 2017

[9]High genetic and antigenic similarity between a swine H3N2 influenza A virus and a prior human influenza vaccine virus: A possible immune pressure-driven cross-species transmission. Pan, Chungen,Jiang, Shibo,Wang, Guiping,Liao, Ming,Zhang, Gui-Hong. 2009

[10]Development of Monoclonal Antibodies Recognizing Linear Epitope: Illustration by Three Bacillus thuringiensis Crystal Proteins of Genetically Modified Cotton, Maize, and Tobacco. Cao, Zhen,Zhang, Wei,Ning, Xiangxue,Wang, Baomin,Cao, Zhen,Li, Qing X.,Liu, Yunjun. 2017

[11]Evolution analysis of the matrix (M) protein genes of 17 H9N2 chicken influenza viruses isolated in northern China during 1998-2008. Huang, Yanyan,Hu, Beixia,Zhang, Xiumei,Wen, Xintian,Cao, Sanjie,Xu, Dong,Khan, Mazhar I.. 2009

[12]Humoral and cellular immune responses to Fasciola gigantica experimental infection in buffaloes. Zhang, WY,Moreau, E,Yang, BZ,Li, ZQ,Hope, JC,Howard, CJ,Huang, WY,Chauvin, A. 2006

[13]Developments on Immunoassays for Pyrethroid Chemicals. Jin, Maojun,Chen, Ge,Du, Pengfei,Zhang, Chan,Cui, Xueyan,She, Yongxin,Zheng, Lufei,Wang, Shanshan,Shao, Hua,Jin, Fen,Wang, Jing,Gee, Shirley J.,Hammock, Bruce D.,Gee, Shirley J.,Hammock, Bruce D.. 2017

[14]Leptin receptor signaling inhibits ovarian follicle development and egg laying in chicken hens. Lei, Ming M.,Chen, Zhe,Shi, Zhen D.,Wu, Si Q.,Li, Xiao W.,Wang, Cong L.. 2014

[15]Synthesis and identification of the ciprofloxacin hapten-protein Conjugates. Huang, Xuan-yun,Huang, Dong-mei,Shi, Yong-fu,Feng, Bing,Yu, Hui-juan,Cai, You-qiong. 2013

[16]Impacts of different expressions of PA-X protein on 2009 pandemic H1N1 virus replication, pathogenicity and host immune responses. Leea, Jinhwa,Yua, Hai,Li, Yonghai,Ma, Jingjiao,Lang, Yuekun,Duff, Michael,Henningson, Jamie,Liu, Qinfang,Li, Yuhao,Nagy, Abdou,Bawa, Bhupinder,Richt, Juergen A.,Ma, Wenjun,Yua, Hai,Liu, Qinfang,Li, Zejun,Tong, Guangzhi,Nagy, Abdou.

[17]Immunoassays for aflatoxins. Li, Peiwu,Zhang, Qi,Zhang, Wen.

[18]A method to label biological molecules with dsDNA coated gold nanoparticles. Xing, Ming,Dong, Yingshan,Xing, Ming,Li, Fangliang,Chen, Xia,Xing, Ming,Li, Fangliang,Chen, Xia,Yu, Zhenxiang.

[19]Experimental infection with bovine ephemeral fever virus and analysis of its antibody response cattle. Zheng, F. Y.,Chen, Q. W.,Li, Z.,Gong, X. W.,Wang, J. D.,Yin, H..

[20]Influenza a virus NS1 protein induced A20 contributes to viral replication by suppressing interferon-induced antiviral response. Feng, Wenjing,Sun, Xiaoning,Zhang, Maolin,Guan, Zhenhong,Duan, Ming,Shi, Ning.

作者其他论文 更多>>

微信小程序