A series of new supramolecular polycations for effective gene transfection

文献类型： 外文期刊

第一作者： Hu, Hao

作者： Hu, Hao;Song, Hai-Qing;Yu, Bing-Ran;Xu, Fu-Jian;Cai, Qing;Xu, Fu-Jian;Cai, Qing;Xu, Fu-Jian;Zhu, Yun

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期刊名称：POLYMER CHEMISTRY （ 影响因子：4.1； 五年影响因子：4.2 ）

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收录情况： SCI

摘要： The development of safe and effective supramolecular polycations has attracted much attention. In this work, a series of novel cyclodextrin (CD)-based supramolecular assemblies were readily prepared via the host-guest interaction by assembling different adamantane-functionalized alpha-CD derivatives with multiple beta-CD-cored polycations. The supramolecular assemblies were investigated in terms of their pDNA-binding capabilities, cytotoxicities, cellular internalization and gene transfection efficiencies in HEK293, HepG2 and C6 cell lines. The supramolecular polycations displayed low cytotoxicities, similar to those of the CD-cored carriers. After self-assemblies, the gene transfection efficiencies and antitumor abilities of the supramolecular carriers were significantly enhanced. The present study demonstrates that such supramolecular preparation of CD-based polycations could provide a flexible strategy for the design and development of new assemblies with high efficiency and low cytotoxicity.

分类号： O63

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