Genomic Organization and Expression of Immunoglobulin Genes in the Chinese Hamster (Cricetulus griseus)

文献类型： 外文期刊

第一作者： Qin, T.

作者： Qin, T.;Zhu, H.;Wang, D.;Hao, H.;Du, W.

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期刊名称：SCANDINAVIAN JOURNAL OF IMMUNOLOGY （ 影响因子：3.487； 五年影响因子：3.199 ）

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收录情况： SCI

摘要： In science, the hamsters are widely used as a model for studying the human diseases because they display many features like humans. The utility of the Chinese hamster as a biology model can be further enhanced by further characterization of the genes encoding components of the immune system. Here, we report the genomic organization and expression of the Chinese hamster immunoglobulin heavy and light chain genes. The Chinese hamster IgH locus contains 268 V-H segments (132 potentially functional genes, 12 ORFs and 124 pseudogenes), 4 D-H segments, 6 J(H) segments, four constant region genes (, , epsilon and ) and one reverse remnant fragment. The Ig locus contains only a single C gene, 4 J segments and 48 V segments (15 potentially functional genes and 33 pseudogenes), whereas the Ig locus contains 4 C genes, but only C3 and C4 each preceded by a J gene segment. A total of 49 V segments (39 potentially functional genes, 3 ORFs and 7 pseudogenes) were identified. Analysis of junctions of the recombined V(D)J transcripts reveals complex diversity in both expressed H and sequences, but the microhomology-directed VJ recombination obviously results in very limited diversity in the Chinese hamster gene despite more potential germline-encoded combinatorial diversity. This is the first study to make a comprehensive analysis of the Ig genes in the Chinese hamster, which provides insights into the Ig genes in placental mammals.

分类号： R392

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