In vitro anti-aflatoxigenic effect and mode of action of cinnamaldehyde against aflatoxin B-1

文献类型： 外文期刊

第一作者： Sun, Qi

作者： Sun, Qi;Liu, Yang;Wang, Ling;Lu, Zhisong

作者机构：

关键词： Cinnamaldehyde;Aflatoxin B1;Antifungal;Antiaflatoxigenic;Antioxidant;Detoxification

期刊名称：INTERNATIONAL BIODETERIORATION & BIODEGRADATION （ 影响因子：4.32； 五年影响因子：4.719 ）

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收录情况： SCI

摘要： Cinnamaldehyde (CIN), a natural extract from Cinnamomum spp., is commonly used for extending the shelf life of selected foods as preservative. In this study, CIN was applied to investigate its effect on aflatoxin B-1 (AFB(1)) biosynthesis of Aspergillus flavus. To elucidate the mechanism of action, the ability of CIN to inhibit fungal growth as well as spore germination of A. flavus was evaluated in vitro. Moreover, the effects of CIN on pellet size, reactive oxygen species formation and lipid peroxidation involved in AFB(1) synthesis were furthermore investigated. The results demonstrated that CIN dose-dependently inhibited AFB(1) production, which is consistent with the significant reduction of both reactive oxygen species and thiobarbituric acid reactive substances level after CIN treatment for three days. In addition, optical microscope observation showed that CIN could effectively postpone spore germination of A. flavus which is unfavorable for hyphae elongation and pellet formation. However, the trend of AFB(1) reduction in YES broth was not exactly consistent with the growth inhibition of A.flavus strain expressed as mycelia dry weight. When fungus was incubated with high concentration of CIN, the degradation rate of up to 14.8% of AFB(1) could be achieved on the 5th day. The present study suggested that CIN suppression of AFB(1) contamination is due to pleiotropic effects that control spore germination, oxidative stress alleviation of fungal cells and aflatoxin detoxification. These results further showed that CIN could be an alternative to chemical fungicides to prevent A. flavus and AFB(1) contamination during grain storage and in the field. (C) 2015 Elsevier Ltd. All rights reserved.

分类号： Q93

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