An ultra high performance liquid chromatography with tandem mass spectrometry method for plasma and cerebrospinal fluid pharmacokinetics of rhein in patients with traumatic brain injury after administration of rhubarb decoction

文献类型： 外文期刊

第一作者： Fan, Rong

作者： Fan, Rong;Luo, Jiekun;Tang, Tao;Xing, Zhihua;Xia, Zian;Peng, Weijun;Wang, Wenzhu;Huang, Wei;Huang, Xi;Wang, Wenzhu;Wang, Wenzhu;Lv, Huiying;Liang, Yizeng;Lu, Hongmei;Yi, Lunzhao

作者机构：

关键词： Blood-brain barrier;Pharmacokinetics;Rhubarb;Traumatic brain injury;Ultra high performance liquid chromatography with tandem mass spectrometry

期刊名称：JOURNAL OF SEPARATION SCIENCE （ 影响因子：3.645； 五年影响因子：2.943 ）

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年卷期：

页码：

收录情况： SCI

摘要： Damage of blood-brain barrier is a common result of traumatic brain injury. This damage can open the blood-brain barrier and allow drug passage. An ultraperformance liquid chromatography with tandem mass spectrometry method was established to determine the concentration of rhein in the biofluids (plasma and cerebrospinal fluid) of patients with a compromised blood-brain barrier following traumatic brain injury after rhubarb administration. Furthermore, the pharmacokinetic profiles were analyzed. A triple-quadruple tandem mass spectrometer with electrospray ionization was used for rhein detection. The mass transition followed was m/z 283.06239.0. The calibration curve was linear in the concentration range of 10-8000 ng/mL for the biofluids. The intra- and interday precisions were less than 10%. The relative standard deviation of recovery was less than 15% in biological matrices. The pharmacokinetic data showed that rhein was rapidly transported into biofluids, and exhibited a peak concentration 1 h after rhubarb administration. The elimination rate of rhein was slow. The AUC(cerebrospinal fluid)/AUC(plasma) (AUC is area under curve) of rhein was approximately 17%, indicating that portions of rhein could pass the impaired blood-brain barrier. The method was successfully applied to quantify rhein in the biofluids of all patients. The data presented can help to guide clinical applications of rhubarb for treating traumatic brain injury.

分类号： O6

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