Simultaneous enantioselective determination of isocarbophos and its main metabolite isocarbophos oxon in rice, soil, and water by chiral liquid chromatography and tandem mass spectrometry

文献类型： 外文期刊

第一作者： Yao, Zhoulin

作者： Yao, Zhoulin;Lin, Mei;Wang, Tianyu;Ping, Xinliang;Wu, Shaohui;Yao, Zhoulin;Xu, Mingfei;Wang, Qiang;Zhang, Hu;Yao, Zhoulin;Xu, Mingfei;Wang, Qiang;Zhang, Hu;Yao, Zhoulin;Xu, Mingfei;Wang, Qiang;Zhang, Hu;Yao, Zhoulin

作者机构：

关键词： Chiral compounds;Enantioselective separation;Isocarbophos;Isocarbophos oxon;Liquid chromatography with tandem mass spectrometry

期刊名称：JOURNAL OF SEPARATION SCIENCE （ 影响因子：3.645； 五年影响因子：2.943 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： An efficient enantioselective method for the simultaneous determination of isocarbophos and its main metabolite isocarbophos oxon in rice, soil, and water was developed using liquid chromatography with tandem mass spectrometry. The enantioseparation was performed on a Chiralpak AD-3R column at 30 degrees C using gradient elution. Target compounds were extracted from soil and rice using acetonitrile with omission of a clean-up procedure, while a C-18 solid-phase extraction column was used for water samples. Quantification was achieved using matrix-matched calibration. The overall mean recoveries for isocarbophos and isocarbophos oxon enantiomers from the five matrices were 89.7-103 and 90.1-98.7%, with relative standard deviations of 2.1-5.4 and 2.5-4.7%, respectively. Moreover, the absolute configurations of isocarbophos oxon enantiomers were determined by liquid chromatography with tandem mass spectrometry through incubation of each isocarbophos enantiomer in soil, the first eluting enantiomer being confirmed as (R)-(-)-isocarbophos oxon. The proposed method was applied to real soil samples and satisfactory results were obtained.

分类号： O6

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