Comparative Proteomic Analysis of Wild-Type and SAP Domain Mutant Foot-and-Mouth Disease Virus-Infected Porcine Cells Identifies the Ubiquitin-Activating Enzyme UBE1 Required for Virus Replication
文献类型: 外文期刊
第一作者: Zhu, Zixiang
作者: Zhu, Zixiang;Yang, Fan;Zhang, Keshan;Cao, Weijun;Jin, Ye;Wang, Guoqing;Mao, Ruoqing;Li, Dan;Guo, Jianhong;Liu, Xiangtao;Zheng, Haixue
作者机构:
关键词: foot-and-mouth disease virus;SAP domain;iTRAQ;quantitative proteomics;pathway analysis
期刊名称:JOURNAL OF PROTEOME RESEARCH ( 影响因子:4.466; 五年影响因子:4.352 )
ISSN:
年卷期:
页码:
收录情况: SCI
摘要: Leader protein (L-Pro) of foot-and-mouth disease virus (FMDV) manipulates the activities of several host proteins to promote viral replication and pathogenicity. L-Pro has a conserved protein domain SAP that is suggested to subvert interferon (IFN) production to block antiviral responses. However, apart from blocking IFN production, the roles of the SAP domain during FMDV infection in host cells remain unknown. Therefore, we identified host proteins associated with the SAP domain of L-Pro by a high-throughput quantitative proteomic approach [isobaric tags for relative and absolute quantitation (iTRAQ) in conjunction with liquid chromatography/electrospray ionization tandem mass spectrometry]. Comparison of the differentially regulated proteins in rA/FMDVA Delta mSAP- versus rA/FMDV-infected SK6 cells revealed 45 down-regulated and 32 up-regulated proteins that were mostly associated with metabolic, ribosome, spliceosome, and ubiquitin-proteasome pathways. The results also imply that the SAP domain has a function similar to SAP-A/B besides its potential protein inhibitor of activated signal transducer and activator of transcription (PIAS) function. One of the identified proteins UBE1 was further analyzed and displayed a novel role for the SAP domain of L-Pro. Overexpression of UBE1 enhanced the replication of FMDV, and knockdown of UBE1 decreased FMDV replication. This shows that FMDV manipulates UBE1 for increased viral replication, and the SAP domain was involved in this process.
分类号: Q7`Q51
- 相关文献
作者其他论文 更多>>
-
Perillaldehyde controls citrus green mold by inhibiting the ribosome biogenesis of Penicillium digitatum and improving citrus disease resistance
作者:Liu, Shuqi;Jiang, Yuxin;Yang, Fan;Wang, Yuqing;Lu, Yongqing;Lai, Weiqiang;Long, Chao-an;Sun, Jiancheng;Yang, Fan;Long, Chao-an;Long, Chao-an
关键词:Perillaldehyde; Penicillium digitatum; Citrus; Green mold; ROS
-
Characterization of the complete plastid genome of Clivia mirabilis (Amaryllidaceae)
作者:Yue, Ling;Feng, Xiu-Li;Li, Dan;Wu, Hai-Hong;Zhao, Xing-Hua;Meng, Jing
关键词:Amaryllidaceae; Clivia mirabilis; phylogenetic analysis; plastid genome
-
A coiled-coil domain mutation in the NLR receptor SbYR1 coordinates plant growth and stress tolerance in sorghum
作者:Li, Dan;Ma, Dianrong;Li, Dan;Zhu, Zhenxing;Qu, Kuangzheng;Li, Jinhong;Lu, Xiaochun;Ma, Dianrong
关键词:NLR; ABA; JA; Flavonoid; Head Smut; Sorghum bicolor
-
Innovative far-infrared radiation assisted pulsed vacuum freeze-drying of banana slices: Drying behaviors, physicochemical properties and microstructural evolution
作者:Xu, Ming-Qiang;Ha, Bu-Er;Yang, Fan;Jiang, Yu-Hao;Zhang, An-An;Lv, Weiqiao;Xiao, Hong-Wei;Xu, Ming-Qiang;Vidyarthi, Sriram K.;Zhang, Feng-Lun
关键词:Far-infrared radiation assisted pulsed vacuum; freeze-drying; Banana slices; Drying behavior; Physicochemical properties; Microstructural evolution
-
Special expression of alanine-aminotransferase1 (OsAlaAT1) improves nitrogen utilization in wheat
作者:Jiao, Bo;Wang, Jiao;Dong, Fushuang;Yang, Fan;Liu, Yongwei;Sun, Lei;Chai, Jianfang;Zhou, Shuo
关键词:
-
Long-term warming and acidification interaction drives plastic acclimation in the diatom Pseudo-nitzschia multiseries
作者:Sun, Yanmin;Zhang, Yanan;Liang, Chengwei;Ye, Naihao;Li, Fang;Sun, Yanmin;Yang, Fan;Xu, Dong;Zhang, Yanan;Liang, Chengwei;Huang, Xintong;Wang, Bingkun;Wang, Yapeng;Sun, Haoming;Ye, Naihao;Duan, Ran;Fu, Fei-Xue;Wang, Zhuonan
关键词:
-
Rapid adaptation of Bacillus thuringiensis to alkaline environments via the L-lactate metabolism pathway regulated by the CRP/FNR family regulator LtmR
作者:Peng, Qi;Qin, Jiaxin;Xu, Hong;Kao, Guiwei;Yang, Fan;Sun, Zhongqin;Zhang, Xin;Song, Fuping;Qin, Jiaxin;Sun, Zhongqin;Guo, Shuyuan;Peng, Qi;Slamti, Leyla
关键词:Bacillus thuringiensis; CRP/FNR family regulator; Alkaline adaptation