Balance between metallothionein and metal response element binding transcription factor 1 is mediated by zinc ions

文献类型： 外文期刊

第一作者： Dong, Gang

作者： Dong, Gang;Chen, Hong;Dou, Ye;Wang, Qinglu;Qi, Meiyu

作者机构：

关键词： metallothionein;metal response element-binding transcription factor-1;Zn2+;metal ion metabolism

期刊名称：MOLECULAR MEDICINE REPORTS （ 影响因子：2.952； 五年影响因子：2.754 ）

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年卷期：

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收录情况： SCI

摘要： Metal ion homeostasis and heavy metal detoxification systems are regulated by certain genes associated with metal ion transport. Metallothionein (MT) and metal response element binding transcription factor 1 (MTF-1) are important regulatory proteins involved in the mediation of intracellular metal ion balance. Differences in the zinc-binding affinities of the zinc fingers of MTF-1 and the alpha- and beta-domains of MT facilitate their regulation of Zn2+ concentration. Alterations in the intracellular concentration of Zn2+ influence the MTF-1 zinc finger number, and MTF-1 containing certain zinc finger numbers regulates the expression of corresponding target genes. The present review evaluates the association between zinc finger number in MTF-1 protein, MTF-1 target genes and the mechanism underlying. MT regulation of the zinc finger number in MTF-1.

分类号： R3

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