Genome-wide identification of allele-specific expression in response to Streptococcus suis 2 infection in two differentially susceptible pig breeds
文献类型: 外文期刊
第一作者: Wu, Huayu
作者: Wu, Huayu;Gaur, Uma;Peng, Xianwen;Li, Lianghua;Sun, Hua;Song, Zhongxu;Dong, Binke;Li, Mingbo;Mei, Shuqi;Liu, Guisheng;Wu, Huayu;Gaur, Uma;Peng, Xianwen;Li, Lianghua;Sun, Hua;Dong, Binke;Mei, Shuqi;Liu, Guisheng;Mekchay, Supamit;Wimmers, Klaus;Ponsuksili, Siriluck;Li, Kui
作者机构:
关键词: Allele specific expression;Disease resistance;Pig;SNP;Streptococcus suis
期刊名称:JOURNAL OF APPLIED GENETICS ( 影响因子:3.24; 五年影响因子:2.756 )
ISSN:
年卷期:
页码:
收录情况: SCI
摘要: Although allele expression imbalance has been recognized in many species, and strongly linked to diseases, no whole transcriptome allele imbalance has been detected in pigs during pathogen infections. The pathogen Streptococcus suis 2 (SS2) causes serious zoonotic disease. Different pig breeds show differential susceptibility/resistance to pathogen infection, but the biological insight is little known. Here we analyzed allele-specific expression (ASE) using the spleen transcriptome of four pigs belonging to two phenotypically different breeds after SS2 infection. The comparative analysis of allele specific SNPs between control and infected animals revealed 882 and 1096 statistically significant differentially expressed allele SNPs (criteria: ratioa parts per thousand 2 or a parts per thousand broken vertical bar 0.5) in Landrace and Enshi black pig, respectively. Twenty nine allelically imbalanced SNPs were further verified by Sanger sequencing, and later six SNPs were quantified by pyrosequencing assay. The pyrosequencing results are in agreement with the RNA-seq results, except two SNPs. Looking at the role of ASE in predisposition to diseases, the discovery of causative variants by ASE analysis might help the pig industry in long term to design breeding programs for improving SS2 resistance.
分类号: Q1
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