Porcine encephalomyocarditis virus strain BD2 isolated from northern China is highly virulent for BALB/c mice

文献类型： 外文期刊

第一作者： Yuan, W.

作者： Yuan, W.;Zhang, X.;Sun, M.;Zhang, L.;Chen, L.;Sun, J.;Yuan, W.;Zhang, X.;Sun, M.;Zhang, L.;Chen, L.;Sun, J.;Yuan, W.;Zhang, X.;Sun, M.;Zhang, L.;Chen, L.;Sun, J.;Hua, R.

作者机构：

关键词： encephalomyocarditis virus;pathogenicity;mice

期刊名称：ACTA VIROLOGICA （ 影响因子：1.162； 五年影响因子：1.255 ）

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收录情况： SCI

摘要： Encephalomyocarditis virus (EMCV) can cause acute myocarditis in young pigs or reproductive failure in sows. The BD2 strain was isolated from the suspected piglets with EMCV in China. In order to establish an experimental animal model of EMCV, eight-weeks-old male BALB/c mice were intraperitonealy inoculated with 0.1 nil of 4x10(5) TCID50 suspension of the EMCV. Infected mice demonstrated hind limb paralysis, and movement disorder. The mortality rate of the infected group was 100% during the one-week observation period. The viral load in the brain of challenged mice gradually increased, with a peak level being 6.53 log CCID50/0.1 ml 5 days post infection. The pathological injury in infected mice was presented as neuronal necrosis. Brown positive staining could be detected in the cytoplasm of cerebral neurons. These results indicate that the porcine EMCV isolated from China could replicate in brain tissues and induce acute encephalitis in BALB/c mice.

分类号： R37

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