Three New Sesquiterpenes with Cytotoxic Activity from Dobinea delavayi

文献类型： 外文期刊

第一作者： Ma, Qing-Yun

作者： Ma, Qing-Yun;Dai, Hao-Fu;Huang, Sheng-Zhuo;Zhao, You-Xing;Cheng, Zhong-Quan;Zhou, Jun;Cheng, Zhong-Quan;Yang, Dan;Yi, Xiang-Hui

作者机构：

关键词： Dobinea delavayi;Podoaceae;sesquiterpenes;anti-cancer activity

期刊名称：PLANTA MEDICA （ 影响因子：3.352； 五年影响因子：3.4 ）

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收录情况： SCI

摘要： Three new sesquiterpenes dobinins A-C (1-3), together with five known compounds, were isolated from the root of Dobinea delavayi. The structures of the three new compounds were determined on the basis of spectroscopic analysis including 1D-, 2D-NMR and MS techniques as well as by comparison of the spectral data with those of analogous compounds reported in the literatures. Compounds 1-3 were screened for antitumor activity in vitro and exhibited definite cytotoxic activity against the human tumor cell line HL-60 with IC50 levels of 8.0 x 10(-5), 4.7 x 10(-5), and 5.1 x 10(-5) M, respectively.

分类号： R9

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