Synergistic Antibacterial Effect of the Combination of epsilon-Polylysine and Nisin against Enterococcus faecalis

文献类型： 外文期刊

第一作者： Liu, Fang

作者： Liu, Fang;Liu, Mei;Wang, Daoying;Geng, Zhiming;Zhang, Muhan;Sun, Chong;Zhu, Yongzhi;Xu, Weimin;Liu, Mei;Xu, Xiaoxi;Du, Lihui

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期刊名称：JOURNAL OF FOOD PROTECTION （ 影响因子：2.077； 五年影响因子：2.224 ）

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收录情况： SCI

摘要： This study evaluated the antibacterial effect of the combination of epsilon-polylysine (epsilon-PL) and nisin against Enterococcus faecalis strains. The combination of epsilon-PL and nisin showed synergistic antibacterial activity against three Enterococcus strains. Scanning electron microscopy and a membrane permeability assay revealed that the combined treatment with epsilon-PL and nisin synergistically damaged the cell morphology of E. faecalis strain R612Z1 cells. Both epsilon-PL and nisin can dissipate the transmembrane electric potential of E. faecalis R612Z1 cells, but these peptides did not affect the transmembrane pH gradient. The combination of epsilon-PL and nisin can produce a high reactive oxygen species level in E. faecalis R612Z1 cells. The results indicated that the uptake of epsilon-PL into cells was promoted through nisin and that the combination of epsilon-PL and nisin could produce a high reactive oxygen species level in E. faecalis R612Z1 cells, leading to cell growth inhibition.

分类号： TS205

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