Comparative proteomics of milk fat globule membrane in different species reveals variations in lactation and nutrition

文献类型: 外文期刊

第一作者: Lu, Jing

作者: Lu, Jing;Zhang, Weiqing;Liu, Lu;Pang, Xiaoyang;Zhang, Shuwen;Lv, Jiaping;Wang, Xinyu;Wang, Xinyu

作者机构:

关键词: Milk fat globule membrane proteome;Human;Cow;Goat;Yak;Lipid catabolic enzymes

期刊名称:FOOD CHEMISTRY ( 影响因子:7.514; 五年影响因子:7.516 )

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收录情况: SCI

摘要: In present study, 312, 554, 175 and 143 proteins were identified and quantified by label-free quantitative proteomics in human, cow, goat and yak milk fat globule membrane (MFGM), respectively. Fifty proteins involved in vesicle mediate transport and milk fat globule secretion were conserved among species. Moreover, proteins involved in lipid synthesis and secretion (xanthine dehydrogenase/oxidase, stomatin and CD36), showed different expression pattern and the host defense proteins exhibited various profiles within species. Notably, the content and activity of lipid catabolic enzymes were significantly higher in human MFGM, which could be indicative of the superior fat utilization in breast fed infants. Our findings unraveled the significant differences in protein composition of human milk and conventionally used substitutes of it. The in-depth study of lipid metabolic enzymes in human MFGM will probably contribute to the improvement of the fat utilization through modulation of lipid catabolic enzymes in infant formula. (C) 2015 Elsevier Ltd. All rights reserved.

分类号: TS2`TS201.2

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