Optimization of selenylation modification for garlic polysaccharide based on immune-enhancing activity

文献类型： 外文期刊

第一作者： Gao, Zhenzhen

作者： Gao, Zhenzhen;Qiu, Shulei;Li, Youying;Wang, Deyun;Liu, Cui;Li, Xiuping;Hou, Ranran;Yue, Chanjuan;Liu, Jie;Hu, Yuanliang;Chen, Jin;Li, Hongquan

作者机构：

关键词： Garlic polysaccharide;Selenylation modification;Lymphocyte proliferation;Cytokines Immune response

期刊名称：CARBOHYDRATE POLYMERS （ 影响因子：9.381； 五年影响因子：8.678 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Garlic polysaccharide (GPS) was modified in selenylation respectively by nitric acid-sodium selenite (NA-SS), glacial acetic acid-selenous acid (GA-SA), glacial acetic acid-sodium selenite (GA-SS) and selenium oxychloride (SOC) methods each under nine modification conditions of L-9 (3(4)) orthogonal design and each to obtain nine selenizing GPSs (sGPSs). Their structures were identified, yields and selenium contents were determined, selenium yields were calculated, and the immune-enhancing activities of four sGPSs with higher selenium yields were compared taking unmodified GPS as control. The results showed that among four methods the selenylation efficiency of NA-SS method were the highest, the activity of sGPS(5) was the strongest and significantly stronger than that of unmodified GPS. This indicates that selenylation modification can significantly enhance the immune-enhancing activity of GPS, NA-SS method is the best method and the optimal conditions are 0.8:1 weight ratio of sodium selenite to GPS, reaction temperature of 70 degrees C and reaction time of 10 h. (C) 2015 Elsevier Ltd. All rights reserved.

分类号： O629`Q53

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