Emergence of a Pseudorabies virus variant with increased virulence to piglets

文献类型: 外文期刊

第一作者: Tong, Wu

作者: Tong, Wu;Liu, Fei;Zheng, Hao;Liang, Chao;Zhou, Yan-jun;Jiang, Yi-feng;Shan, Tong-ling;Gao, Fei;Li, Guo-xin;Tong, Guang-zhi;Tong, Wu;Zheng, Hao;Li, Guo-xin;Tong, Guang-zhi

作者机构:

关键词: Pathogenicity;Pseudorabies virus;Variant

期刊名称:VETERINARY MICROBIOLOGY ( 影响因子:3.293; 五年影响因子:3.599 )

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年卷期:

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收录情况: SCI

摘要: Pseudorabies virus (PRV) causes Pseudorabies (PR), an economically important disease in domestic swine. PR outbreaks on pig farms caused by PRV variant strains in Bartha-K61-vaccinated pigs have resulted in considerable economic losses in China since 2011. In this study, the pathogenicity of the PRV variant JS-2012 strain to pigs was investigated by experimentally inoculating piglets of different ages in comparison with a classic virulent PRV SC strain. The JS-2012 strain caused an earlier onset of clinical signs and higher mortality in 15, 30, and 60-day-old pigs, as compared with a classic virulent PRV SC strain. The Bartha-K61 vaccination provided complete protection against challenge with classical virulent PRV, but only partial protection against challenge with the JS-2012 strain in piglets. In conclusion, the increased virulence of the PRV variant may have partly contributed to the PR outbreak in China. (C) 2015 Elsevier B.V. All rights reserved.

分类号: S8

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