Tannin as a gatekeeper of pH-responsive mesoporous silica nanoparticles for drug delivery
文献类型： 外文期刊
第一作者： Hu, Chunlin
作者： Hu, Chunlin;Zheng, Zhen;Wang, Jing;Liu, Yuan;Wang, Xinling;Yu, Lingxue;Jiang, Yifeng;Tong, Guangzhi;Zhou, Yanjun
作者机构：
期刊名称：RSC ADVANCES （ 影响因子：3.361； 五年影响因子：3.39 ）
ISSN：
年卷期：
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收录情况： SCI
摘要： Tannin grafted on mesoporous silica nanoparticles (tannin-MSNs) was synthesized by the amidation reaction of carboxyl benzyl borate with amino group modified MSN. Tannin-MSNs were an MCM-41 type of mesoporous material with a uniform diameter of about 150 nm. The XRD and N-2 adsorption/desorption isotherm results demonstrated that the rhodamine was effectively loaded and the pores of MSN were blocked by tannin. Rhodamine as a model cargo was used to evaluate the loading and releasing behaviors of tannin-MSNs. The drug release rate of tannin-MSNs was pH dependent. An in vitro cellular cytotoxicity test indicated that tannin-MSNs were highly biocompatible and suitable to be used as drug carriers. The cellular uptake was investigated by confocal laser scan microscopy. The results showed that tannin-MSNs are promising platforms to construct a pH-responsive controlled drug delivery system for cancer and stomach therapy.
分类号： O6
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