Pharmacokinetics and bioavailability of flumequine in blunt snout bream (Megalobrama amblycephala) after intravascular and oral administrations
文献类型： 外文期刊
第一作者： Xu, N.
作者： Xu, N.;Dong, J.;Yang, Y.;Yang, Q.;Liu, Y.;Ai, X.;Xu, N.;Liu, Y.;Ai, X.
作者机构：
期刊名称：JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS （ 影响因子：1.786； 五年影响因子：1.7 ）
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年卷期：
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收录情况： SCI
摘要： In this study, the pharmacokinetic profile of flumequine (FMQ) was investigated in blunt snout bream (Megalobrama amblycephala) after intravascular (3mg/kg body weight (b.w.)) and oral (50mg/kg b.w.) administrations. The plasma samples were determinedby ultra-performance liquid chromatography (UPLC) with fluorescence detection. After intravascular administration, plasma concentration-time curves were best described by a two-compartment open model. The distribution half-life (t(1/2 alpha)), elimination half-life (t(1/2 beta)), and area under the concentration-time curve (AUC) of blunt snout bream were 0.6 h, 25.0 h, and 10612.7 h center dot mu g/L, respectively. After oral administration, a two-compartment open model with first-order absorption was also best fit the data of plasma. The t(1/2 alpha), t(1/2 beta), peak concentration (C-max), time-to-peak concentration (T-max), and AUC of blunt snout bream were estimated to be 2.5 h, 19.7 h, 3946.5 mu g/L, 1.4 h, and 56618.1 h. mu g/L, respectively. The oral bioavailability (F) was 32.0%. The pharmacokinetics of FMQ in blunt snout bream displayed low bioavailability, rapid absorption, and rapid elimination.
分类号： S85
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