Protection of Chickens against Very Virulent Marek's Disease Virus (MDV) by an Infectious Clone of Meq-Null MDV Vaccination

文献类型： 外文期刊

第一作者： Cui, Ning

作者： Cui, Ning;Su, Shuai;Cui, Zhizhong;Sun, Peng;Li, Yanpeng;Zhu, Hongfei;Ding, Jiabo;Kang, Mengjiao

作者机构：

关键词： Infectious clone;Marek's disease virus;Meq null;Protective immunity

期刊名称：PAKISTAN VETERINARY JOURNAL （ 影响因子：1.318； 五年影响因子：0.954 ）

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收录情况： SCI

摘要： To evaluate the immune-protective effect of GX0101 Delta meq bacterial artificial chromosome (BAC) which contains an infectious meq-null Marek's disease virus genome, 1-day-old SPF chickens were reared separately in isolators with positive filtered air. On 1 day of age, chickens were immunized with 20 mu g of GX0101 Delta meq BAC suspended in PBS, and challenge infection with 500 PFU very virulent rMd5 were performed at day 5 and 12 post-immunization separately. During 90 days after challenge, all chickens were recorded and checked for necropsy. The protective index of the two vaccines used was 80 and 40 for CVI988/Rispens and GX0101 Delta meq BAC, respectively, after challenged with the very virulent (vv) virus rMd5 at day 5 post-immunization. When challenged with rMd5 at day 12 postimmunization, the protection index of GX0101 Delta meq BAC increased to 67%. Except that GX0101 Delta meq BAC can confer protection against vv MDV, a delay in the development of MD could be observed in some chickens vaccinated with GX0101 Delta meq BAC. On the other hand, compared with CVI988/Rispens, the rescue of GX0101 Delta meq BAC in the body is a prerequisite for access to protection. Therefore, there is a blank period after immunization, which provides a chance for infection with the wild MDV. (c) 2015 PVJ. All rights reserved

分类号： S85

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