Polysialic acid biosynthesis and production in Escherichia coli: current state and perspectives

文献类型： 外文期刊

第一作者： Lin, Bai-Xue

作者： Lin, Bai-Xue;Tao, Yong;Qiao, Yu;Shi, Bo

作者机构：

关键词： Polysialic acid biosynthesis;Escherichia coli;Metabolic engineering;Process engineering

期刊名称：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY （ 影响因子：4.813； 五年影响因子：4.697 ）

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年卷期：

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收录情况： SCI

摘要： Polysialic acid (PSA) is a unique polysaccharide that plays critical roles in many bioprocesses, which makes it useful in a wide range of biomedical applications. The increased demand for PSA has led to considerable efforts to improve its production using bacteria, such as Escherichia coli. Bioprocess optimization and metabolic engineering have allowed the efficient production of PSA. This review aims to summarize the metabolism of PSA with an emphasis on the importance of the key pathway components. In addition, this review provides an update on state of the art PSA production using E. coli with a special emphasis on strategies of strain engineering and process development for the enhanced production of PSA.

分类号： Q939.9`Q81

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