Hybrid quadrupole-orbitrap mass spectrometry analysis with accurate-mass database and parallel reaction monitoring for high-throughput screening and quantification of multi-xenobiotics in honey

文献类型： 外文期刊

第一作者： Li, Yi

作者： Li, Yi;Zhang, Jinzhen;Jin, Yue;Wang, Lin;Zhao, Wen;Zhang, Wenwen;Zhou, Jinhui;Li, Yi;Zhang, Jinzhen;Jin, Yue;Wang, Lin;Zhao, Wen;Zhou, Jinhui;Li, Yi;Zhang, Jinzhen;Jin, Yue;Wang, Lin;Zhao, Wen;Zhou, Jinhui;Zhai, Lifei;Zhang, Yaping;Zhang, Yongxin

作者机构：

关键词： Honey;Hybrid quadrupole-orbitrap;Accurate-mass database;Parallel reaction monitoring;Multi-xenobiotics

期刊名称：JOURNAL OF CHROMATOGRAPHY A （ 影响因子：4.759； 五年影响因子：4.302 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： This study reports a rapid, automated screening and quantification method for the determination of multi-xenobiotic residues in honey using ultra-high performance liquid chromatography-hybrid quadrupole-Orbitrap mass spectrometry (UHPLC-Q-Orbitrap) with a user-built accurate-mass database plus parallel reaction monitoring (PRM). The database contains multi-xenobiotic information including formulas, adduct types, theoretical exact mass and retention time, characteristic fragment ions, ion ratios, and mass accuracies. A simple sample preparation method was developed to reduce xenobiotic loss in the honey samples. The screening method was validated based on retention time deviation, mass accuracy via full scan-data-dependent MS/MS (full scan-ddMS2), multi-isotope ratio, characteristic ion ratio, sensitivity, and positive/negative switching performance between the spiked sample and corresponding standard solution. The quantification method based on the PRM mode is a promising new quantitative tool which we validated in terms of selectivity, linearity, recovery (accuracy), repeatability (precision), decision limit (CC alpha), detection capability (CC beta), matrix effects, and carry-over. The optimized methods proposed in this study enable the automated screening and quantification of 157 compounds in less than 15 min in honey. The results of this study, as they represent a convenient protocol for large-scale screening and quantification, also provide a research approach for analysis of various contaminants in other matrices. (C) 2015 Elsevier B.V. All rights reserved.

分类号： O65

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